SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Rifas Shiman Sheryl)
 

Search: WFRF:(Rifas Shiman Sheryl) > Genetic effects on ...

Genetic effects on the timing of parturition and links to fetal birth weight.

Solé Navais, Pol (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Flatley, Christopher (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Steinthorsdottir, Valgerdur (author)
show more...
Vaudel, Marc (author)
Juodakis, Julius (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Chen, Jing (author)
Laisk, Triin (author)
LaBella, Abigail L (author)
Westergaard, David (author)
Bacelis, Jonas, 1984 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Brumpton, Ben (author)
Skotte, Line (author)
Borges, Maria C (author)
Helgeland, Øyvind (author)
Mahajan, Anubha (author)
Wielscher, Matthias (author)
Lin, Frederick (author)
Briggs, Catherine (author)
Wang, Carol A (author)
Moen, Gunn-Helen (author)
Beaumont, Robin N (author)
Bradfield, Jonathan P (author)
Abraham, Abin (author)
Thorleifsson, Gudmar (author)
Gabrielsen, Maiken E (author)
Ostrowski, Sisse R (author)
Modzelewska, Dominika (author)
Nohr, Ellen A (author)
Hypponen, Elina (author)
Srivastava, Amit (author)
Talbot, Octavious (author)
Allard, Catherine (author)
Williams, Scott M (author)
Menon, Ramkumar (author)
Shields, Beverley M (author)
Sveinbjornsson, Gardar (author)
Xu, Huan (author)
Melbye, Mads (author)
Lowe, William (author)
Bouchard, Luigi (author)
Oken, Emily (author)
Pedersen, Ole B (author)
Gudbjartsson, Daniel F (author)
Erikstrup, Christian (author)
Sørensen, Erik (author)
Lie, Rolv T (author)
Teramo, Kari (author)
Hallman, Mikko (author)
Juliusdottir, Thorhildur (author)
Hakonarson, Hakon (author)
Ullum, Henrik (author)
Hattersley, Andrew T (author)
Sletner, Line (author)
Merialdi, Mario (author)
Rifas-Shiman, Sheryl L (author)
Steingrimsdottir, Thora (author)
Scholtens, Denise (author)
Power, Christine (author)
West, Jane (author)
Nyegaard, Mette (author)
Capra, John A (author)
Skogholt, Anne H (author)
Magnus, Per (author)
Andreassen, Ole A (author)
Thorsteinsdottir, Unnur (author)
Grant, Struan F A (author)
Qvigstad, Elisabeth (author)
Pennell, Craig E (author)
Hivert, Marie-France (author)
Hayes, Geoffrey M (author)
Jarvelin, Marjo-Riitta (author)
McCarthy, Mark I (author)
Lawlor, Deborah A (author)
Nielsen, Henriette S (author)
Mägi, Reedik (author)
Rokas, Antonis (author)
Hveem, Kristian (author)
Stefansson, Kari (author)
Feenstra, Bjarke (author)
Njolstad, Pål (author)
Muglia, Louis J (author)
Freathy, Rachel M (author)
Johanson, Stefan (author)
Zhang, Ge (author)
Jacobsson, Bo, 1960 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
show less...
 (creator_code:org_t)
2023
2023
English.
In: Nature genetics. - 1546-1718. ; 55:4, s. 559-567
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n=195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n=136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal-fetal relationship between gestational duration and birth weight.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Find more in SwePub

By the author/editor
Solé Navais, Pol
Flatley, Christo ...
Steinthorsdottir ...
Vaudel, Marc
Juodakis, Julius
Chen, Jing
show more...
Laisk, Triin
LaBella, Abigail ...
Westergaard, Dav ...
Bacelis, Jonas, ...
Brumpton, Ben
Skotte, Line
Borges, Maria C
Helgeland, Øyvin ...
Mahajan, Anubha
Wielscher, Matth ...
Lin, Frederick
Briggs, Catherin ...
Wang, Carol A
Moen, Gunn-Helen
Beaumont, Robin ...
Bradfield, Jonat ...
Abraham, Abin
Thorleifsson, Gu ...
Gabrielsen, Maik ...
Ostrowski, Sisse ...
Modzelewska, Dom ...
Nohr, Ellen A
Hypponen, Elina
Srivastava, Amit
Talbot, Octaviou ...
Allard, Catherin ...
Williams, Scott ...
Menon, Ramkumar
Shields, Beverle ...
Sveinbjornsson, ...
Xu, Huan
Melbye, Mads
Lowe, William
Bouchard, Luigi
Oken, Emily
Pedersen, Ole B
Gudbjartsson, Da ...
Erikstrup, Chris ...
Sørensen, Erik
Lie, Rolv T
Teramo, Kari
Hallman, Mikko
Juliusdottir, Th ...
Hakonarson, Hako ...
Ullum, Henrik
Hattersley, Andr ...
Sletner, Line
Merialdi, Mario
Rifas-Shiman, Sh ...
Steingrimsdottir ...
Scholtens, Denis ...
Power, Christine
West, Jane
Nyegaard, Mette
Capra, John A
Skogholt, Anne H
Magnus, Per
Andreassen, Ole ...
Thorsteinsdottir ...
Grant, Struan F ...
Qvigstad, Elisab ...
Pennell, Craig E
Hivert, Marie-Fr ...
Hayes, Geoffrey ...
Jarvelin, Marjo- ...
McCarthy, Mark I
Lawlor, Deborah ...
Nielsen, Henriet ...
Mägi, Reedik
Rokas, Antonis
Hveem, Kristian
Stefansson, Kari
Feenstra, Bjarke
Njolstad, Pål
Muglia, Louis J
Freathy, Rachel ...
Johanson, Stefan
Zhang, Ge
Jacobsson, Bo, 1 ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Obstetrics Gynae ...
Articles in the publication
Nature genetics
By the university
University of Gothenburg

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view