Genetic effects on the timing of parturition and links to fetal birth weight.

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Solé Navais, PolGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology (author)

Genetic effects on the timing of parturition and links to fetal birth weight.

Article/chapterEnglish2023

Publisher, publication year, extent ...

2023

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LIBRIS-ID:oai:gup.ub.gu.se/325091
https://gup.ub.gu.se/publication/325091URI
https://doi.org/10.1038/s41588-023-01343-9DOI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n=195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n=136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal-fetal relationship between gestational duration and birth weight.

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Flatley, ChristopherGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xflchr (author)
Steinthorsdottir, Valgerdur (author)
Vaudel, Marc (author)
Juodakis, JuliusGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjouju (author)
Chen, Jing (author)
Laisk, Triin (author)
LaBella, Abigail L (author)
Westergaard, David (author)
Bacelis, Jonas,1984Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xbacjo (author)
Brumpton, Ben (author)
Skotte, Line (author)
Borges, Maria C (author)
Helgeland, Øyvind (author)
Mahajan, Anubha (author)
Wielscher, Matthias (author)
Lin, Frederick (author)
Briggs, Catherine (author)
Wang, Carol A (author)
Moen, Gunn-Helen (author)
Beaumont, Robin N (author)
Bradfield, Jonathan P (author)
Abraham, Abin (author)
Thorleifsson, Gudmar (author)
Gabrielsen, Maiken E (author)
Ostrowski, Sisse R (author)
Modzelewska, Dominika (author)
Nohr, Ellen A (author)
Hypponen, Elina (author)
Srivastava, Amit (author)
Talbot, Octavious (author)
Allard, Catherine (author)
Williams, Scott M (author)
Menon, Ramkumar (author)
Shields, Beverley M (author)
Sveinbjornsson, Gardar (author)
Xu, Huan (author)
Melbye, Mads (author)
Lowe, William (author)
Bouchard, Luigi (author)
Oken, Emily (author)
Pedersen, Ole B (author)
Gudbjartsson, Daniel F (author)
Erikstrup, Christian (author)
Sørensen, Erik (author)
Lie, Rolv T (author)
Teramo, Kari (author)
Hallman, Mikko (author)
Juliusdottir, Thorhildur (author)
Hakonarson, Hakon (author)
Ullum, Henrik (author)
Hattersley, Andrew T (author)
Sletner, Line (author)
Merialdi, Mario (author)
Rifas-Shiman, Sheryl L (author)
Steingrimsdottir, Thora (author)
Scholtens, Denise (author)
Power, Christine (author)
West, Jane (author)
Nyegaard, Mette (author)
Capra, John A (author)
Skogholt, Anne H (author)
Magnus, Per (author)
Andreassen, Ole A (author)
Thorsteinsdottir, Unnur (author)
Grant, Struan F A (author)
Qvigstad, Elisabeth (author)
Pennell, Craig E (author)
Hivert, Marie-France (author)
Hayes, Geoffrey M (author)
Jarvelin, Marjo-Riitta (author)
McCarthy, Mark I (author)
Lawlor, Deborah A (author)
Nielsen, Henriette S (author)
Mägi, Reedik (author)
Rokas, Antonis (author)
Hveem, Kristian (author)
Stefansson, Kari (author)
Feenstra, Bjarke (author)
Njolstad, Pål (author)
Muglia, Louis J (author)
Freathy, Rachel M (author)
Johanson, Stefan (author)
Zhang, Ge (author)
Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

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In:Nature genetics55:4, s. 559-5671546-1718

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By the author/editor: Solé Navais, Pol; Flatley, Christo ...; Steinthorsdottir ...; Vaudel, Marc; Juodakis, Julius; Chen, Jing; show more...; Laisk, Triin; LaBella, Abigail ...; Westergaard, Dav ...; Bacelis, Jonas, ...; Brumpton, Ben; Skotte, Line; Borges, Maria C; Helgeland, Øyvin ...; Mahajan, Anubha; Wielscher, Matth ...; Lin, Frederick; Briggs, Catherin ...; Wang, Carol A; Moen, Gunn-Helen; Beaumont, Robin ...; Bradfield, Jonat ...; Abraham, Abin; Thorleifsson, Gu ...; Gabrielsen, Maik ...; Ostrowski, Sisse ...; Modzelewska, Dom ...; Nohr, Ellen A; Hypponen, Elina; Srivastava, Amit; Talbot, Octaviou ...; Allard, Catherin ...; Williams, Scott ...; Menon, Ramkumar; Shields, Beverle ...; Sveinbjornsson, ...; Xu, Huan; Melbye, Mads; Lowe, William; Bouchard, Luigi; Oken, Emily; Pedersen, Ole B; Gudbjartsson, Da ...; Erikstrup, Chris ...; Sørensen, Erik; Lie, Rolv T; Teramo, Kari; Hallman, Mikko; Juliusdottir, Th ...; Hakonarson, Hako ...; Ullum, Henrik; Hattersley, Andr ...; Sletner, Line; Merialdi, Mario; Rifas-Shiman, Sh ...; Steingrimsdottir ...; Scholtens, Denis ...; Power, Christine; West, Jane; Nyegaard, Mette; Capra, John A; Skogholt, Anne H; Magnus, Per; Andreassen, Ole ...; Thorsteinsdottir ...; Grant, Struan F ...; Qvigstad, Elisab ...; Pennell, Craig E; Hivert, Marie-Fr ...; Hayes, Geoffrey ...; Jarvelin, Marjo- ...; McCarthy, Mark I; Lawlor, Deborah ...; Nielsen, Henriet ...; Mägi, Reedik; Rokas, Antonis; Hveem, Kristian; Stefansson, Kari; Feenstra, Bjarke; Njolstad, Pål; Muglia, Louis J; Freathy, Rachel ...; Johanson, Stefan; Zhang, Ge; Jacobsson, Bo, 1 ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Nature genetics

By the university: University of Gothenburg

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