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Characterization of...
Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31
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- Zhang, Li (författare)
- East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China; Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol SKLM, Beijing 100101, Peoples R China; Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA
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- Zhang, Jingyu (författare)
- East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
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- Ren, Biao (författare)
- Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China.;Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China
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- Lu, Wanying (författare)
- East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
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- Hou, Chengjian (författare)
- East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
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- Wang, Jian (författare)
- Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol SKLM, Beijing 100101, Peoples R China
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- Ma, Xiaolong (författare)
- Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol SKLM, Beijing 100101, Peoples R China
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- Ma, Rong (författare)
- East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
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- Liu, Mei (författare)
- Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol SKLM, Beijing 100101, Peoples R China
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- Liu, Zhiheng (författare)
- Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol SKLM, Beijing 100101, Peoples R China
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- Li, Jin-Ping (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Ding, Kan (författare)
- Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, Shanghai 201203, Peoples R China; Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
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- Dai, Huanqin (författare)
- Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol SKLM, Beijing 100101, Peoples R China
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- Zhang, Lixin (författare)
- East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
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- Liu, Xueting (författare)
- East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
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(creator_code:org_t)
- 2020-08-24
- 2020
- Engelska.
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Ingår i: Applied Microbiology and Biotechnology. - : Springer Science and Business Media LLC. - 0175-7598 .- 1432-0614. ; 104:19, s. 8267-8278
- Relaterad länk:
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The current global demand for novel anti-TB drugs has drawn urgent attention on the discovery of natural product compounds with anti-TB activity. Lots of efforts have emphasized on environmental samples from unexplored or underexplored natural habits and identified numerous rare actinomycete taxa producing structurally diverse bioactive natural products. Herein, we report a survey of the rare actinobacteria diversity in Xinjiang region together with the discovery of anti-TB active natural products from these strains. We have collected 17 soil samples at different sites with different environmental conditions, from which 39 rare actinobacteria were identified by using a selective isolation strategy with 5 media variations. Among those isolated strains, XJ31 was identified as a new Nocardia sp. based on 16S rRNA gene analysis. Through one strain-many compounds (OSMAC) strategy combined with anti-Bacillus Calmette-Guérin bioassay-guided isolation, two groups of compounds were identified. They were twelve siderophores (nocardimicins, 1-12) and two anthraquinones (brasiliquinones, 13 and 14) and ten of them were identified as new compounds. The structures of the purified compounds were elucidated using HR-ESI-MS, 1D NMR, and 2D NMR techniques. The anti-TB bioassays revealed that the two benz[α]anthraquinones have potent activity against BCG (MICs = 25 μM), which can be used as a promising start point for further anti-TB drug development.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Xinjiang desert
- Nocardiasp
- Anti-BCG
- Brasiliquinone
- Nocardimicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Zhang, Li
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Zhang, Jingyu
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Ren, Biao
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Lu, Wanying
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Hou, Chengjian
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Wang, Jian
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Ma, Xiaolong
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Ma, Rong
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Liu, Mei
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Liu, Zhiheng
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Li, Jin-Ping
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Ding, Kan
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Dai, Huanqin
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Zhang, Lixin
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Liu, Xueting
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Mikrobiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
- Artiklar i publikationen
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Applied Microbio ...
- Av lärosätet
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Uppsala universitet