Circulating Chemerin Is Elevated in Women With Preeclampsia.

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Circulating Chemerin Is Elevated in Women With Preeclampsia.

Bartho, Lucy A (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, 163 Studley Rd, Heidelberg, Vic 3084, Australia.

Kandel, Manju (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Walker, Susan P (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

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Cluver, Catherine A (författare): Stellenbosch Univ, Dept Obstet & Gynecol, ZA-7505 Cape Town, South Africa.

Hastie, Roxanne (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Stellenbosch Univ, Dept Obstet & Gynecol, ZA-7505 Cape Town, South Africa.

Bergman, Lina, 1982 (författare): Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynecol, ZA-7505 Cape Town, South Africa; Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Obstet & Gynecol, S-40530 Gothenburg, Sweden

Pritchard, Natasha (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Cannon, Ping (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Nguyen, Tuong-Vi (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Wong, Georgia P (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

MacDonald, Teresa M (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Keenan, Emerson (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Hannan, Natalie J (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Tong, Stephen (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

Kaitu'u-Lino, Tu'uhevaha J (författare): Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.

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Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia.;Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, 163 Studley Rd, Heidelberg, Vic 3084, Australia. Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic 3084, Australia. (creator_code:org_t)

2023-03-07
2023
Engelska.
Ingår i: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 164:5

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Preeclampsia is a severe complication of pregnancy. Chemerin is an adipokine secreted from adipose tissue and highly expressed in placenta. This study evaluated the biomarker potential of circulating chemerin to predict preeclampsia.Maternal plasma and placenta were collected from women with early-onset preeclampsia (<34 weeks), with preeclampsia and eclampsia, or before preeclampsia diagnosis (36 weeks). Human trophoblast stem cells were differentiated into syncytiotrophoblast or extravillous trophoblasts across 96hours. Cells were cultured in 1% O2 (hypoxia) or 5% O2 (normoxia). Chemerin was measured by enzyme-linked immunosorbent assay (ELISA) and RARRES2 (gene coding chemerin) by reverse transcription-quantitative polymerase chain reaction.Circulating chemerin was increased in 46 women with early-onset preeclampsia (<34 weeks) compared to 17 controls (P < .0006). Chemerin was increased in placenta from 43 women with early-onset preeclampsia compared to 24 controls (P < .0001). RARRES2 was reduced in placenta from 43 women with early-onset preeclampsia vs 24 controls (P < .0001). Chemerin was increased in plasma from 26 women with established preeclampsia (P = .006), vs 15 controls. Circulating chemerin was increased in 23 women who later developed preeclampsia vs 182 who did not (P = 3.23 × 10-6). RARRES2 was reduced in syncytiotrophoblast (P = .005) or extravillous trophoblasts (P < .0001). Hypoxia increased RARRES2 expression in syncytiotrophoblast (P = .01) but not cytotrophoblast cells.Circulating chemerin was elevated in women with early-onset preeclampsia, established preeclampsia, and preceding preeclampsia diagnosis of preeclampsia. RARRES2 was dysregulated in placenta complicated by preeclampsia and may be regulated through hypoxia. Chemerin may have potential as a biomarker for preeclampsia but would need to be combined with other biomarkers.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Female
Humans
Pregnancy
Biomarkers
metabolism
Hypoxia
metabolism
Placenta
metabolism
Pre-Eclampsia
diagnosis
Trophoblasts
metabolism
chemerin

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Av författaren/redakt...: Bartho, Lucy A; Kandel, Manju; Walker, Susan P; Cluver, Catherin ...; Hastie, Roxanne; Bergman, Lina, 1 ...; visa fler...; Pritchard, Natas ...; Cannon, Ping; Nguyen, Tuong-Vi; Wong, Georgia P; MacDonald, Teres ...; Keenan, Emerson; Hannan, Natalie ...; Tong, Stephen; Kaitu'u-Lino, Tu ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

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