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Management of Cereb...
Management of Cerebral Venous Thrombosis Due to Adenoviral COVID-19 Vaccination.
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- Scutelnic, Adrian (författare)
- Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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- Krzywicka, Katarzyna (författare)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
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- Mbroh, Joshua (författare)
- Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen, Germany; Department of Neurology & Stroke, Eberhard-Karls University, Tuebingen, Germany
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visa fler...
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- van de Munckhof, Anita (författare)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
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- van Kammen, Mayte Sánchez (författare)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
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- de Sousa, Diana Aguiar (författare)
- CEEM and Institute of Anatomy, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
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- Lindgren, Erik, 1993 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Gothenburg, Sweden
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- Jood, Katarina, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Gothenburg, Sweden
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- Günther, Albrecht (författare)
- Department of Neurology, Jena University Hospital, Jena, Germany
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- Hiltunen, Sini (författare)
- Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
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- Putaala, Jukka (författare)
- Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
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- Tiede, Andreas (författare)
- Clinic for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
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- Maier, Frank (författare)
- Department of Neurology, Caritas Hospital Saarbrücken, Saarbrücken, Germany
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- Kern, Rolf (författare)
- Department of Neurology, Kempten Hospital, Kempten, Germany
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- Bartsch, Thorsten (författare)
- Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany
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- Althaus, Katharina (författare)
- Department of Neurology, Ulm University Hospital, Ulm, Germany
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- Ciccone, Alfonso (författare)
- Department of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy
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- Wiedmann, Markus (författare)
- Department of Neurosurgery, Oslo University Hospital, Oslo, Norway
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- Skjelland, Mona (författare)
- Department of Neurosurgery, Oslo University Hospital, Oslo, Norway
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- Medina, Antonio (författare)
- Department of Neurology, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
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- Cuadrado-Godia, Elisa (författare)
- Department of Neurology, University Hospital del Mar, Barcelona, Spain
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- Cox, Thomas (författare)
- Department of Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
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- Aujayeb, Avinash (författare)
- Respiratory Department, Northumbria Healthcare NHS Foundation Trust, Cramlington, United Kingdom,Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland,Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
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- Raposo, Nicolas (författare)
- Department of Neurology, Toulouse University Hospital, Toulouse, France
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- Garambois, Katia (författare)
- Stroke Unit, University Hospital of Grenoble, Grenoble, France
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- Payen, Jean-Francois (författare)
- Stroke Unit, University Hospital of Grenoble, Grenoble, France
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- Vuillier, Fabrice (författare)
- Stroke Unit, University Hospital of Besancon, Besancon, France
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- Franchineau, Guillaume (författare)
- Department of Intensive Care, Centre Hospitalier Intercommunal de Poissy Saint Germain en Laye, Poissy, France
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- Timsit, Serge (författare)
- Neurology and Stroke Unit, Centre Hospitalier Universitaire de Brest, CHU Brest, Brest, France
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- Bougon, David (författare)
- Department of Critical Care, Annecy Genevois Hospital, Annecy, France
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- Dubois, Marie-Cécile (författare)
- Department of Anesthesia and Intensive Care, University Hospital of Poitiers, Poitiers, France
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- Tawa, Audrey (författare)
- Department of Anesthesia and Intensive Care, University Hospital of Rennes, Rennes, France
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- Tracol, Clement (författare)
- Department of Neurology, CHU Rennes, Rennes, France
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- De Maistre, Emmanuel (författare)
- Department of Biological Haematology, CHU Dijon, Dijon, France
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- Bonneville, Fabrice (författare)
- Department of Neuroradiology, Toulouse University Hospital, Toulouse, France
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- Vayne, Caroline (författare)
- Department of Hematology and Hemostasis, Tours University Hospital, Tours, France
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- Mengel, Annerose (författare)
- Department of Neurology and Stroke, Eberhard-Karls University, Tuebingen, Germany
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- Michalski, Dominik (författare)
- Department of Neurology, Leipzig University Hospital, Leipzig, Germany
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- Pelz, Johann (författare)
- Department of Neurology, Leipzig University Hospital, Leipzig, Germany
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- Wittstock, Matthias (författare)
- Department of Neurology, University Hospital Rostock, Rostock, Germany
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- Bode, Felix (författare)
- Department of Neurology, Universitätsklinikum Bonn, Bonn, Germany
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- Zimmermann, Julian (författare)
- Department of Neurology, Universitätsklinikum Bonn, Bonn, Germany
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- Schouten, Judith (författare)
- Department of Neurology, Rijnstate Hospital Arnhem, Arnhem, Netherlands
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- Buture, Alina (författare)
- Acute Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland
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- Murphy, Sean (författare)
- Acute Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland
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- Palma, Vincenzo (författare)
- Department of Neuroradiology, Ospedale del Mare, Naples, Italy
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- Negro, Alberto (författare)
- Department of Neuroradiology, Ospedale del Mare, Naples, Italy
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- Gutschalk, Alexander (författare)
- Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
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- Nagel, Simon (författare)
- Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
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- Schoenenberger, Silvia (författare)
- Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany,Department of Neuroradiology, Policlinico di Bari, Bari, Italy,Department of Neurology, Hospital de Cascais Dr José de Almeida, Cascais, Portugal,Division of Neurology, University of British Columbia, Vancouver Stroke Program, BC, Vancouver, Canada
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- Frisullo, Giovanni (författare)
- Department of Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
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- Zanferrari, Carla (författare)
- Department of Neurology, Azienda Ospedaliera di Melegnano e della Martesana, Melegnano, Italy
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- Grillo, Francesco (författare)
- Stroke Unit, Department of Clinical and Experimental Medicine, University Hospital G. Martino, Messina, Italy
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- Giammello, Fabrizio (författare)
- Translational Molecular Medicine and Surgery, XXXV Cycle, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
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- Martin, Mar Morin (författare)
- Department of Neurology, Hospital Complex of Toledo, Toledo, Spain,Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands,Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal,Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
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- Cervera, Alvaro (författare)
- Department of Neurology, Royal Darwin Hospital, NT, Tiwi, Australia
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- Burrow, Jim (författare)
- Department of Neurology, Royal Darwin Hospital, NT, Tiwi, Australia
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- Esperon, Carlos Garcia (författare)
- Department of Neurology, John Hunter Hospital, NSW, Newcastle, Australia
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- Chew, Beng Lim Alvin (författare)
- Department of Neurology, John Hunter Hospital, NSW, Newcastle, Australia
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- Kleinig, Timothy J (författare)
- Department of Neurology, Royal Adelaide Hospital, SA, Adelaide, Australia
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- Soriano, Cristina (författare)
- Department of Neurology, Hospital General de Castellón, Castelló, Spain
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Zimatore, Domenico S (författare)
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- Petruzzellis, Marco (författare)
- Department of Neurology, AOU Consorziale Policlinico di Bari, Bari, Italy
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- Elkady, Ahmed (författare)
- Department of Neurology, Saudi German Hospital, Jeddah, Saudi Arabia
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Miranda, Miguel S (författare)
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- Fernandes, João (författare)
- Department of Neurology, Norra Älvsborgs Länssjukhus, Trollhättan, Sweden
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- Vogel, Åslög Hellström (författare)
- Department of Internal Medicine, Skåne University Hospital, Lund, Sweden
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- Johansson, Elias, 1984 (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Neurovetenskaper
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- Philip, Anemon Puthuppallil (författare)
- Department of Neurology, Hamilton General Hospital, ON, Hamilton, Canada
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- Coutts, Shelagh B (författare)
- Department of Clinical Neurosciences, Radiology, and Community Health Sciences, Foothills Medical Centre, AB, Calgary, Canada,Division of Neurology, University of Alberta Hospital, AB, Edmonton, Canada
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- Bal, Simerpreet (författare)
- Department of Clinical Neurosciences, Radiology, and Community Health Sciences, Foothills Medical Centre, AB, Calgary, Canada
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Buck, Brian (författare)
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- Legault, Catherine (författare)
- Department of Neurology and Neurosurgery, McGill University Health Centre, QC, Montreal, Canada
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- Blacquiere, Dylan (författare)
- Division of Neurology, The Ottawa Hospital, ON, Ottawa, Canada
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- Katzberg, Hans D (författare)
- Department of Neuromuscular Medicine, Toronto General Hospital, ON, Toronto, Canada
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Field, Thalia S (författare)
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- Dizonno, Vanessa (författare)
- Division of Neurology, University of British Columbia, Vancouver Stroke Program, BC, Vancouver, Canada
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- Gattringer, Thomas (författare)
- Department of Neurology, Medical University of Graz, Graz, Austria
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- Jacobi, Christian (författare)
- Department of Neurology, Nordwest Hospital, Frankfurt am Main, Germany
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- Devroye, Annemie (författare)
- Department of Neurology, University Hospitals Leuven, Leuven, Belgium
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- Lemmens, Robin (författare)
- Department of Neurology, University Hospitals Leuven, Leuven, Belgium
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- Kristoffersen, Espen Saxhaug (författare)
- Department of Neurology, Akershus University Hospital, Lørenskog, Norway
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- di Poggio, Monica Bandettini (författare)
- Department of Neuroscience, Policlinic San Martino Hospital, Genoa, Italy
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- Ghiasian, Masoud (författare)
- Department of Neurology, Sina Hospital, Hamadan University of Medical Science, Hamadan, Iran
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- Karapanayiotides, Theodoros (författare)
- Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece
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- Chatterton, Sophie (författare)
- Department of Neurology, St. Vincent's Hospital, NSW, Sydney, Australia
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- Wronski, Miriam (författare)
- Royal North Shore Hospital, NSW, Sydney, Australia
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- Ng, Karl (författare)
- Department of Neurology and Clinical Neurophysiology, Royal North Shore Hospital and The University of Sydney, NSW, Sydney, Australia
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- Kahnis, Robert (författare)
- Department of Neurology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany
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- Geeraerts, Thomas (författare)
- Department of Anaesthesiology and Critical Care, University Toulouse 3-Paul-Sabatier, University Hospital of Toulouse, Hôpital Pierre-Paul Riquet, CHU Toulouse-Purpan, Toulouse, France
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- Reiner, Peggy (författare)
- Service de neurologie, hôpital Lariboisière Université Paris-7, AP–HP, Paris Cedex 10, France
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- Cordonnier, Charlotte (författare)
- University of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille, France
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- Middeldorp, Saskia (författare)
- Department of Internal Medicine & Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, Netherlands
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- Levi, Marcel (författare)
- National Institute for Health Research University College London Hospitals (UCLH) Biomedical Research Centre, London, United Kingdom; Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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van Gorp, Eric C M (författare)
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- van de Beek, Diederik (författare)
- Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
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- Brodard, Justine (författare)
- Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Kremer Hovinga, Johanna A (författare)
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Kruip, Marieke J H A (författare)
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- Tatlisumak, Turgut (författare)
- Department of Neurology & Stroke, Eberhard-Karls University, Tuebingen, Germany
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Ferro, José M (författare)
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Coutinho, Jonathan M (författare)
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- Arnold, Marcel (författare)
- Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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- Poli, Sven (författare)
- Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen, Germany; Department of Neurology & Stroke, Eberhard-Karls University, Tuebingen, Germany
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- Heldner, Mirjam R (författare)
- Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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(creator_code:org_t)
- 2022-07-04
- 2022
- Engelska.
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Ingår i: Annals of neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 92:4, s. 562-573
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cerebral venous thrombosis (CVT) caused by vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus-based severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality.We used data from an international prospective registry of patients with CVT after the adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable, or definite VITT-CVT cases included until January 18, 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis.Ninety-nine patients with VITT-CVT from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11 of 24 (46%), and 28 of 37 (76%) of the patients diagnosed in March, April, and from May onward, respectively, were treated in-line with VITT recommendations (p<0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 [32%] vs 29/55 [52%], adjusted odds ratio [OR]=0.43, 95% confidence interval [CI]=0.16-1.19). However, patients who received immunomodulation had lower mortality (19/65 [29%] vs 24/34 [70%], adjusted OR=0.19, 95% CI=0.06-0.58). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 [33%] vs 13/35 [37%], adjusted OR=0.70, 95% CI=0.24-2.04). Mortality was also not significantly influenced by platelet transfusion (17/27 [63%] vs 26/72 [36%], adjusted OR=2.19, 95% CI=0.74-6.54).In patients with VITT-CVT, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. ANN NEUROL 2022;92:562-573.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Adenoviridae
- Anticoagulants
- therapeutic use
- COVID-19
- COVID-19 Vaccines
- adverse effects
- Humans
- Immunoglobulins
- Intravenous
- therapeutic use
- Intracranial Thrombosis
- SARS-CoV-2
- Vaccination
- adverse effects
- Venous Thrombosis
- complications
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- art (ämneskategori)
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Scutelnic, Adria ...
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Krzywicka, Katar ...
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Mbroh, Joshua
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van de Munckhof, ...
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van Kammen, Mayt ...
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de Sousa, Diana ...
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Lindgren, Erik, ...
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Jood, Katarina, ...
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Günther, Albrech ...
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Hiltunen, Sini
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Putaala, Jukka
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Tiede, Andreas
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Maier, Frank
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Althaus, Kathari ...
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Ciccone, Alfonso
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Wiedmann, Markus
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Skjelland, Mona
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Medina, Antonio
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Cuadrado-Godia, ...
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Cox, Thomas
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Aujayeb, Avinash
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Raposo, Nicolas
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Garambois, Katia
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Payen, Jean-Fran ...
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Franchineau, Gui ...
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Timsit, Serge
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Bougon, David
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Dubois, Marie-Cé ...
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Tawa, Audrey
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Tracol, Clement
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De Maistre, Emma ...
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Bonneville, Fabr ...
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Vayne, Caroline
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Mengel, Annerose
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Michalski, Domin ...
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Pelz, Johann
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Wittstock, Matth ...
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Bode, Felix
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Zimmermann, Juli ...
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Schouten, Judith
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Buture, Alina
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Murphy, Sean
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Palma, Vincenzo
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Negro, Alberto
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Gutschalk, Alexa ...
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Nagel, Simon
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Schoenenberger, ...
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Frisullo, Giovan ...
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Zanferrari, Carl ...
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Grillo, Francesc ...
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Giammello, Fabri ...
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Martin, Mar Mori ...
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Cervera, Alvaro
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Burrow, Jim
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Esperon, Carlos ...
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Chew, Beng Lim A ...
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Kleinig, Timothy ...
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Soriano, Cristin ...
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Zimatore, Domeni ...
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Petruzzellis, Ma ...
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Elkady, Ahmed
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Miranda, Miguel ...
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Fernandes, João
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Vogel, Åslög Hel ...
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Johansson, Elias ...
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Philip, Anemon P ...
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Coutts, Shelagh ...
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Bal, Simerpreet
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Buck, Brian
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Legault, Catheri ...
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Blacquiere, Dyla ...
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Katzberg, Hans D
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Field, Thalia S
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Dizonno, Vanessa
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Gattringer, Thom ...
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Jacobi, Christia ...
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Devroye, Annemie
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Lemmens, Robin
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Kristoffersen, E ...
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di Poggio, Monic ...
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Ghiasian, Masoud
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Karapanayiotides ...
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Chatterton, Soph ...
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Wronski, Miriam
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Ng, Karl
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Kahnis, Robert
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Geeraerts, Thoma ...
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Reiner, Peggy
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Cordonnier, Char ...
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Middeldorp, Sask ...
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Levi, Marcel
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van Gorp, Eric C ...
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van de Beek, Die ...
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Brodard, Justine
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Kremer Hovinga, ...
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Kruip, Marieke J ...
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Tatlisumak, Turg ...
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Ferro, José M
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Coutinho, Jonath ...
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Arnold, Marcel
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Poli, Sven
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Heldner, Mirjam ...
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