Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants.

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McWhinney, Sean R (author)

Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants.

Article/chapterEnglish2023

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2023

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LIBRIS-ID:oai:gup.ub.gu.se/325709
https://gup.ub.gu.se/publication/325709URI
https://doi.org/10.1017/S0033291723000223DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:152159220URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact.We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations.BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI.We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Abé, ChristophKarolinska Institutet (author)
Alda, Martin (author)
Benedetti, Francesco (author)
Bøen, Erlend (author)
Del Mar Bonnin, Caterina (author)
Borgers, Tiana (author)
Brosch, Katharina (author)
Canales-Rodríguez, Erick J (author)
Cannon, Dara M (author)
Dannlowski, Udo (author)
Diaz-Zuluaga, Ana M (author)
Dietze, Lorielle M F (author)
Elvsåshagen, Torbjørn (author)
Eyler, Lisa T (author)
Fullerton, Janice M (author)
Goikolea, Jose M (author)
Goltermann, Janik (author)
Grotegerd, Dominik (author)
Haarman, Bartholomeus C M (author)
Hahn, Tim (author)
Howells, Fleur M (author)
Ingvar, MartinKarolinska Institutet (author)
Jahanshad, Neda (author)
Kircher, Tilo T J (author)
Krug, Axel (author)
Kuplicki, Rayus T (author)
Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
Lemke, Hannah (author)
Liberg, Benny (author)
Lopez-Jaramillo, Carlos (author)
Malt, Ulrik F (author)
Martyn, Fiona M (author)
Mazza, Elena (author)
McDonald, Colm (author)
McPhilemy, Genevieve (author)
Meier, Sandra (author)
Meinert, Susanne (author)
Meller, Tina (author)
Melloni, Elisa M T (author)
Mitchell, Philip B (author)
Nabulsi, Leila (author)
Nenadic, Igor (author)
Opel, Nils (author)
Ophoff, Roel A (author)
Overs, Bronwyn J (author)
Pfarr, Julia-Katharina (author)
Pineda-Zapata, Julian A (author)
Pomarol-Clotet, Edith (author)
Raduà, Joaquim (author)
Repple, Jonathan (author)
Richter, Maike (author)
Ringwald, Kai G (author)
Roberts, Gloria (author)
Ross, Alex (author)
Salvador, Raymond (author)
Savitz, Jonathan (author)
Schmitt, Simon (author)
Schofield, Peter R (author)
Sim, Kang (author)
Stein, Dan J (author)
Stein, Frederike (author)
Temmingh, Henk S (author)
Thiel, Katharina (author)
Thomopoulos, Sophia I (author)
van Haren, Neeltje E M (author)
Vargas, Cristian (author)
Vieta, Eduard (author)
Vreeker, Annabel (author)
Waltemate, Lena (author)
Yatham, Lakshmi N (author)
Ching, Christopher R K (author)
Andreassen, Ole A (author)
Thompson, Paul M (author)
Hajek, Tomas (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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In:Psychological medicine53:14, s. 6743-67531469-8978

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By the author/editor: McWhinney, Sean ...; Abé, Christoph; Alda, Martin; Benedetti, Franc ...; Bøen, Erlend; Del Mar Bonnin, ...; show more...; Borgers, Tiana; Brosch, Katharin ...; Canales-Rodrígue ...; Cannon, Dara M; Dannlowski, Udo; Diaz-Zuluaga, An ...; Dietze, Lorielle ...; Elvsåshagen, Tor ...; Eyler, Lisa T; Fullerton, Janic ...; Goikolea, Jose M; Goltermann, Jani ...; Grotegerd, Domin ...; Haarman, Barthol ...; Hahn, Tim; Howells, Fleur M; Ingvar, Martin; Jahanshad, Neda; Kircher, Tilo T ...; Krug, Axel; Kuplicki, Rayus ...; Landén, Mikael, ...; Lemke, Hannah; Liberg, Benny; Lopez-Jaramillo, ...; Malt, Ulrik F; Martyn, Fiona M; Mazza, Elena; McDonald, Colm; McPhilemy, Genev ...; Meier, Sandra; Meinert, Susanne; Meller, Tina; Melloni, Elisa M ...; Mitchell, Philip ...; Nabulsi, Leila; Nenadic, Igor; Opel, Nils; Ophoff, Roel A; Overs, Bronwyn J; Pfarr, Julia-Kat ...; Pineda-Zapata, J ...; Pomarol-Clotet, ...; Raduà, Joaquim; Repple, Jonathan; Richter, Maike; Ringwald, Kai G; Roberts, Gloria; Ross, Alex; Salvador, Raymon ...; Savitz, Jonathan; Schmitt, Simon; Schofield, Peter ...; Sim, Kang; Stein, Dan J; Stein, Frederike; Temmingh, Henk S; Thiel, Katharina; Thomopoulos, Sop ...; van Haren, Neelt ...; Vargas, Cristian; Vieta, Eduard; Vreeker, Annabel; Waltemate, Lena; Yatham, Lakshmi ...; Ching, Christoph ...; Andreassen, Ole ...; Thompson, Paul M; Hajek, Tomas; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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