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Plasma biomarkers i...
Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort
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Ferreira, P. C. L. (author)
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Zhang, Y. J. (author)
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Snitz, B. (author)
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Chang, C. C. H. (author)
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Bellaver, B. (author)
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Jacobsen, E. (author)
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Kamboh, M. I. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Pascoal, T. A. (author)
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Villemagne, V. L. (author)
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Ganguli, M. (author)
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2023-03-06
- 2023
- English.
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:10, s. 4507-4519
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- IntroductionPlasma biomarkers-cost effective, non-invasive indicators of Alzheimer's disease (AD) and related disorders (ADRD)-have largely been studied in clinical research settings. Here, we examined plasma biomarker profiles and their associated factors in a population-based cohort to determine whether they could identify an at-risk group, independently of brain and cerebrospinal fluid biomarkers. MethodsWe measured plasma phosphorylated tau181 (p-tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid beta (A beta)42/40 ratio in 847 participants from a population-based cohort in southwestern Pennsylvania. ResultsK-medoids clustering identified two distinct plasma A beta 42/40 modes, further categorizable into three biomarker profile groups: normal, uncertain, and abnormal. In different groups, plasma p-tau181, NfL, and GFAP were inversely correlated with A beta 42/40, Clinical Dementia Rating, and memory composite score, with the strongest associations in the abnormal group. DiscussionAbnormal plasma A beta 42/40 ratio identified older adult groups with lower memory scores, higher dementia risks, and higher ADRD biomarker levels, with potential implications for population screening. HighlightsPopulation-based plasma biomarker studies are lacking, particularly in cohorts without cerebrospinal fluid or neuroimaging data.In the Monongahela-Youghiogheny Healthy Aging Team study (n = 847), plasma biomarkers associated with worse memory and Clinical Dementia Rating (CDR), apolipoprotein E epsilon 4, and greater age.Plasma amyloid beta (A beta)42/40 ratio levels allowed clustering participants into abnormal, uncertain, and normal groups.Plasma A beta 42/40 correlated differently with neurofilament light chain, glial fibrillary acidic protein, phosphorylated tau181, memory composite, and CDR in each group.Plasma biomarkers can enable relatively affordable and non-invasive community screening for evidence of Alzheimer's disease and related disorders pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- aging
- Alzheimer's disease and related disorders
- cluster modeling
- cognitive impairment
- epidemiology
- Monongahela-Youghiogheny Healthy
- Aging Team (MYHAT)
- plasma biomarker
- population-based cohort
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ferreira, P. C. ...
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Zhang, Y. J.
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Snitz, B.
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Chang, C. C. H.
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Bellaver, B.
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Jacobsen, E.
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show more...
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Kamboh, M. I.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Pascoal, T. A.
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Villemagne, V. L ...
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Ganguli, M.
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Karikari, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg