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Shekka Espinosa, AaronGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.
(author)
Differences between cardiac troponin I vs. T according to the duration of myocardial ischaemia
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-02-27
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Oxford University Press (OUP),2023
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LIBRIS-ID:oai:gup.ub.gu.se/325915
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https://gup.ub.gu.se/publication/325915URI
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https://doi.org/10.1093/ehjacc/zuad017DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512494URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Aims Cardiac troponin T (cTnT) and troponin I (cTnI) are expressed as an obligate 1:1 complex in the myocardium. However, blood levels of cTnI often rise much higher than that of cTnT in myocardial infarction (MI), whereas cTnT is often higher in patients with stable conditions such as atrial fibrillation. Here we examine high-sensitive (hs) cTnI and hs-cTnT after different durations of experimental cardiac ischaemia. Methods and results hs-cTnI, hs-cTnT, and the hs-cTnT/hs-cTnI ratio were measured in plasma samples from rats before and at 30 and 120 min after 5, 10, 15, and 30 min of myocardial ischaemia. The animals were killed after 120 min of reperfusion, and the infarct volume and volume at risk were measured. hs-cTnI, hs-cTnT, and the hs-cTnT/hs-cTnI ratio were also measured in plasma samples collected from patients with ST-elevation myocardial infarction (STEMI). hs-cTnT and hs-cTnI increased over 10-fold in all rats subjected to ischaemia. The increase of hs-cTnI and hs-cTnT after 30 min was similar, resulting in a hs-cTnI/hs-cTnT ratio around 1. The hs-cTnI/hs-cTnT ratio was also around 1 in blood samples collected at 120 min in rats subjected to 5 or 10 min of ischaemia where no localized necrosis was observed. In contrast, the hs-cTnI/hs-cTnT ratio at 2 h was 3.6-5.5 after longer ischaemia that induced cardiac necrosis. The large hs-cTnI/hs-cTnT ratio was confirmed in patients with anterior STEMI. Conclusion Both hs-cTnI and hs-cTnT increased similarly after brief periods of ischaemia that did not cause overt necrosis, whereas the hs-cTnI/hs-cTnT ratio tended to increase following longer ischaemia that induced substantial necrosis. A low hs-cTnI/hs-cTnT ratio around 1 may signify non-necrotic cTn release.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Hussain, ShafaatGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xhussh
(author)
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Al-awar, Amin,1989Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Sahlgrenska Center for Cancer Research (SCCR),Univ Gothenburg, Inst Clin Sci,Sahlgrenska Acad, Sahlgrenska Ctr Canc Res, Dept Med Radiat Sci, S-40530 Gothenburg, Sweden.(Swepub:gu)xalawa
(author)
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Jha, SandeepGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.
(author)
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Soliman, Ahmed Elmahdy,1994Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xeahme
(author)
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Kalani, Mana,1986Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xkmana
(author)
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Kakaei, Yalda,1989Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xkakya
(author)
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Zulfaj, Ermir,1993Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xzuler
(author)
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Aune, Emma,1991Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xaunem
(author)
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Poller, Angela,1988Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xpolla
(author)
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Bobbio, EmanueleGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xbobem
(author)
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Thorleifsson, Sigurdur,1980Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xtsigu
(author)
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Zeijlon, RickardGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.
(author)
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Gudmundsson, ThorsteinnGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xgudmt
(author)
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Wernbom, Mathias,1968Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,Univ Gothenburg, Inst Neurosci & Physiol, Dept Hlth & Rehabil, Sahlgrenska Acad, S-40530 Gothenburg, Sweden.(Swepub:gu)xwemat
(author)
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Lindahl, Bertil,1957-Uppsala universitet,Kardiologi(Swepub:uu)belin227
(author)
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Polte, Christian LarsGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xpolch
(author)
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Omerovic, Elmir,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xomeel
(author)
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Hammarsten, O.Sahlgrens Univ Hosp, Dept Clin Chem, S-41345 Gothenburg, Sweden.
(author)
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Redfors, BjörnGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.(Swepub:gu)xredbj
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
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In:European Heart Journal-Acute Cardiovascular Care: Oxford University Press (OUP)12:6, s. 355-3632048-87262048-8734
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