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A unified classific...
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
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Bernhardt, A. M. (author)
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Tiedt, S. (author)
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Teupser, D. (author)
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show more...
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Dichgans, M. (author)
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Meyer, B. (author)
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Gempt, J. (author)
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Kuhn, P. H. (author)
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Simons, M. (author)
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Palleis, C. (author)
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Weidinger, E. (author)
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Nubling, G. (author)
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Holdt, L. (author)
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Honikl, L. (author)
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Gasperi, C. (author)
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Giesbertz, P. (author)
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Muller, S. A. (author)
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Breimann, S. (author)
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Lichtenthaler, S. F. (author)
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Kuster, B. (author)
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Mann, M. (author)
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Imhof, A. (author)
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Barth, T. (author)
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Hauck, S. M. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Otto, M. (author)
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Weichert, W. (author)
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Hemmer, B. (author)
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Levin, J. (author)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Ebiomedicine. - : Elsevier BV. - 2352-3964. ; 89
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomics along with improved neuroimaging methods, are accelerating this development. This calls for a consensus framework that is broadly applicable and provides a spot-on overview of the clinical validity of novel biomarkers. We propose a harmonized terminology and a uniform concept that stratifies biomarkers according to clinical context of use and evidence levels, adapted from existing frameworks in oncology with a strong focus on (epi) genetic markers and treatment context. We demonstrate that this framework allows for a consistent assessment of clinical validity across disease entities and that sufficient evidence for many clinical applications of protein biomarkers is lacking. Our framework may help to identify promising biomarker candidates and classify their applications by clinical context, aiming for routine clinical use of (protein) biomarkers in neurology. Copyright (c) 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Biomarker
- Neurology
- Proteomics
- Protein
- Clinical utility
- Analytical
- validity
- fibrillary acidic protein
- alzheimers-disease
- cerebrospinal-fluid
- multiple-sclerosis
- alpha-synuclein
- neurofilament light
- serum
- biomarkers
- diagnosis
- csf
- marker
- General & Internal Medicine
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bernhardt, A. M.
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Tiedt, S.
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Teupser, D.
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Dichgans, M.
-
Meyer, B.
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Gempt, J.
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show more...
-
Kuhn, P. H.
-
Simons, M.
-
Palleis, C.
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Weidinger, E.
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Nubling, G.
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Holdt, L.
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Honikl, L.
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Gasperi, C.
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Giesbertz, P.
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Muller, S. A.
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Breimann, S.
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Lichtenthaler, S ...
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Kuster, B.
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Mann, M.
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Imhof, A.
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Barth, T.
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Hauck, S. M.
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Zetterberg, Henr ...
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Otto, M.
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Weichert, W.
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Hemmer, B.
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Levin, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Ebiomedicine
- By the university
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University of Gothenburg