Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota

Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation of gut microbiota composition and are considered as promising nutritional strategy for the treatment of metabolic diseases. In the present study, we assessed the separated and combined effects of inulin and rhubarb on diet-induced metabolic disease in mice. We showed that supplementation with both inulin and rhubarb abolished the total body and fat mass gain upon high-fat and high-sucrose diet (HFHS) as well as several obesity-associated metabolic disorders. These effects were associated with increased energy expenditure, lower whitening of the brown adipose tissue, higher mitochondria activity and increased expression of lipolytic markers in white adipose tissue. Despite modifications of intestinal gut microbiota and bile acid compositions by inulin or rhubarb alone, combination of both inulin and rhubarb had minor additional impact on these parameters. However, the combination of inulin and rhubarb increased the expression of several antimicrobial peptides and higher goblet cell numbers, thereby suggesting a reinforcement of the gut barrier. Together, these results suggest that the combination of inulin and rhubarb in mice potentiates beneficial effects of separated rhubarb and inulin on HFHS-related metabolic disease and could be considered as nutritional strategy for the prevention and treatment of obesity and related pathologies.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
obesity
high-fat diet high-sucrose
prebiotics
brown adipose tissue
energy expenditure
inulin
rhubarb extract
gut microbiota
gut microbiota
induced obesity
insulin sensitivity
rheum-undulatum
fiber
acids
health
inflammation
prebiotics
anthraquinones
Gastroenterology & Hepatology
Microbiology

Van Hul, M. (författare)
Roumain, M. (författare)
Paquot, A. (författare)
d'Oplinter, A. D. (författare)
Suriano, Francesco,1987Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xsurfr (författare)
Everard, A. (författare)
Delzenne, N. M. (författare)
Muccioli, G. G. (författare)
Cani, P. D. (författare)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi (creator_code:org_t)

Av författaren/redakt...: Regnier, M.; Van Hul, M.; Roumain, M.; Paquot, A.; d'Oplinter, A. D ...; Suriano, Frances ...; visa fler...; Everard, A.; Delzenne, N. M.; Muccioli, G. G.; Cani, P. D.; visa färre...

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