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Normal neonatal TRE...
Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis
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- Gudmundsdottir, J. A. (author)
- Landspitali University Hospital,Natl Univ Hosp Reykjavik, Iceland
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- Thorleifsson, Sigurdur, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Lundback, V. (author)
- Karolinska Institutet,Karolinska universitetssjukhuset,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Gongrich, C. (author)
- Karolinska Institutet,Karolinska universitetssjukhuset,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Lingman Framme, Jenny, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden; Halland Hosp Halmstad, Sweden
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- Kindgren, Erik (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Skaraborgs Hosp Skovde, Sweden
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- Rydenman, Karin, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden
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- Ludviksson, B. R. (author)
- Landspitali University Hospital,Natl Univ Hosp Iceland, Iceland
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- Bjarnadottir, H. (author)
- Landspitali University Hospital,Natl Univ Hosp Iceland, Iceland
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- Runarsdottir, S. (author)
- Landspitali University Hospital,Natl Univ Hosp Iceland, Iceland
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- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg,Chalmers Univ Technol, Sweden; Univ Gothenburg, Sweden
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- Zetterstrom, R. H. (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden
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- Lindgren, Susanne, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden
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- Thorgeirsdottir, Sigridur (author)
- Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Clinical Immunology. - : Elsevier BV. - 1521-6616 .- 1521-7035. ; 249
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Abstract
Subject headings
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- Objective: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate neonatal levels of T-cell receptor excision circles (TRECs) and kappa-deleting element excision circles (KRECs), as markers of T-and B-cell output at birth, in patients with early onset JIA.Methods: TRECs and KRECs were quantitated by multiplex qPCR from dried blood spots (DBS), collected 2-5 days after birth, in 156 children with early onset JIA and in 312 matched controls.Results: When analysed from neonatal dried blood spots, the median TREC level was 78 (IQR 55-113) in JIA cases and 88 (IQR 57-117) copies/well in controls. The median KREC level was 51 (IQR 35-69) and 53 (IQR 35-74) copies/well, in JIA cases and controls, respectively. Stratification by sex and age at disease onset did not reveal any difference in the levels of TRECs and KRECs.Conclusion: T-and B-cell output at birth, as measured by TREC and KREC levels in neonatal dried blood spots, does not differ in children with early onset JIA compared to controls.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Arthritis juvenile
- Central tolerance
- Autoimmunity
- Infant newborn
- T-cell receptor
- T lymphocytes
- B lymphocytes
- b-cells
- tolerance
- subtypes
- Immunology
- T-cell receptor
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gudmundsdottir, ...
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Thorleifsson, Si ...
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Lundback, V.
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Gongrich, C.
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Lingman Framme, ...
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Kindgren, Erik
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Rydenman, Karin, ...
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Ludviksson, B. R ...
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Bjarnadottir, H.
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Runarsdottir, S.
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Nilsson, Staffan ...
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Zetterstrom, R. ...
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Ekwall, Olov, 19 ...
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Lindgren, Susann ...
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Thorgeirsdottir, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Clinical Immunol ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Karolinska Institutet
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Linköping University