p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study

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MARC

Kobel, M. (author)

p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study

Article/chapterEnglish2023

Publisher, publication year, extent ...

2023-03-22
Wiley,2023

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/326546
https://gup.ub.gu.se/publication/326546URI
https://doi.org/10.1002/cjp2.311DOI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Our objective was to test whether p53 expression status is associated with survival for women diagnosed with the most common ovarian carcinoma histotypes (high-grade serous carcinoma [HGSC], endometrioid carcinoma [EC], and clear cell carcinoma [CCC]) using a large multi-institutional cohort from the Ovarian Tumor Tissue Analysis (OTTA) consortium. p53 expression was assessed on 6,678 cases represented on tissue microarrays from 25 participating OTTA study sites using a previously validated immunohistochemical (IHC) assay as a surrogate for the presence and functional effect of TP53 mutations. Three abnormal expression patterns (overexpression, complete absence, and cytoplasmic) and the normal (wild type) pattern were recorded. Survival analyses were performed by histotype. The frequency of abnormal p53 expression was 93.4% (4,630/4,957) in HGSC compared to 11.9% (116/973) in EC and 11.5% (86/748) in CCC. In HGSC, there were no differences in overall survival across the abnormal p53 expression patterns. However, in EC and CCC, abnormal p53 expression was associated with an increased risk of death for women diagnosed with EC in multivariate analysis compared to normal p53 as the reference (hazard ratio [HR] = 2.18, 95% confidence interval [CI] 1.36-3.47, p = 0.0011) and with CCC (HR = 1.57, 95% CI 1.11-2.22, p = 0.012). Abnormal p53 was also associated with shorter overall survival in The International Federation of Gynecology and Obstetrics stage I/II EC and CCC. Our study provides further evidence that functional groups of TP53 mutations assessed by abnormal surrogate p53 IHC patterns are not associated with survival in HGSC. In contrast, we validate that abnormal p53 IHC is a strong independent prognostic marker for EC and demonstrate for the first time an independent prognostic association of abnormal p53 IHC with overall survival in patients with CCC.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
ovarian cancer
high-grade serous carcinoma
endometrioid
clear cell
TP53
p53
prognosis
grade serous carcinoma
endometrioid carcinoma
tp53 mutation
expression
cancer
algorithm
cell
Pathology

Added entries (persons, corporate bodies, meetings, titles ...)

Kang, E. Y. (author)
Weir, A. (author)
Rambau, P. F. (author)
Lee, C. H. (author)
Nelson, G. S. (author)
Ghatage, P. (author)
Meagher, N. S. (author)
Riggan, M. J. (author)
Alsop, J. (author)
Anglesio, M. S. (author)
Beckmann, M. W. (author)
Bisinotto, C. (author)
Boisen, M. (author)
Boros, J. (author)
Brand, A. H. (author)
Brooks-Wilson, A. (author)
Carney, M. E. (author)
Coulson, P. (author)
Courtney-Brooks, M. (author)
Cushing-Haugen, K. L. (author)
Cybulski, C. (author)
Deen, S. (author)
El-Bahrawy, M. A. (author)
Elishaev, E. (author)
Erber, R. (author)
Fereday, S. (author)
Fischer, A. (author)
Gayther, S. A. (author)
Barquin-Garcia, A. (author)
Gentry-Maharaj, A. (author)
Gilks, C. B. (author)
Gronwald, H. (author)
Grube, M. (author)
Harnett, P. R. (author)
Harris, H. R. (author)
Hartkopf, A. D. (author)
Hartmann, A. (author)
Hein, A. (author)
Hendley, J. (author)
Hernandez, B. Y. (author)
Huang, Y. J. (author)
Jakubowska, A. (author)
Jimenez-Linan, M. (author)
Jones, M. E. (author)
Kennedy, C. J. (author)
Kluz, T. (author)
Koziak, J. M. (author)
Lesnock, J. (author)
Lester, J. (author)
Lubinski, J. (author)
Longacre, T. A. (author)
Lycke, MariaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xlycma (author)
Mateoiu, ConstantinaGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine (author)
McCauley, B. M. (author)
McGuire, V. (author)
Ney, B. (author)
Olawaiye, A. (author)
Orsulic, S. (author)
Osorio, A. (author)
Paz-Ares, L. (author)
Cajal, T. R. Y. (author)
Rothstein, J. H. (author)
Ruebner, M. (author)
Schoemaker, M. J. (author)
Shah, M. T. (author)
Sharma, R. (author)
Sherman, M. E. (author)
Shvetsov, Y. B. (author)
Singh, N. (author)
Steed, H. (author)
Storr, S. J. (author)
Talhouk, A. (author)
Traficante, N. (author)
Wang, C. (author)
Whittemore, A. S. (author)
Widschwendter, M. (author)
Wilkens, L. R. (author)
Winham, S. J. (author)
Benitez, J. (author)
Berchuck, A. (author)
Bowtell, D. D. (author)
dos Reis, F. J. C. (author)
Campbell, I. (author)
Cook, L. S. (author)
DeFazio, A. (author)
Doherty, J. A. (author)
Fasching, P. A. (author)
Fortner, R. T. (author)
Garcia, M. J. (author)
Goodman, M. T. (author)
Goode, E. L. (author)
Gronwald, J. (author)
Huntsman, D. G. (author)
Karlan, B. Y. (author)
Kelemen, L. E. (author)
Kommoss, S. (author)
Le, N. D. (author)
Martin, S. G. (author)
Menon, U. (author)
Modugno, F. (author)
Pharoah, P. D. P. (author)
Schildkraut, J. M. (author)
Sieh, W. (author)
Staebler, A. (author)
Sundfeldt, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xsukar (author)
Swerdlow, A. J. (author)
Ramus, S. J. (author)
Brenton, J. D. (author)
Aocs Grp, Aocs Grp (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

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In:Journal of Pathology Clinical Research: Wiley9:3, s. 208-2222056-4538

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By the author/editor: Kobel, M.; Kang, E. Y.; Weir, A.; Rambau, P. F.; Lee, C. H.; Nelson, G. S.; show more...; Ghatage, P.; Meagher, N. S.; Riggan, M. J.; Alsop, J.; Anglesio, M. S.; Beckmann, M. W.; Bisinotto, C.; Boisen, M.; Boros, J.; Brand, A. H.; Brooks-Wilson, A ...; Carney, M. E.; Coulson, P.; Courtney-Brooks, ...; Cushing-Haugen, ...; Cybulski, C.; Deen, S.; El-Bahrawy, M. A ...; Elishaev, E.; Erber, R.; Fereday, S.; Fischer, A.; Gayther, S. A.; Barquin-Garcia, ...; Gentry-Maharaj, ...; Gilks, C. B.; Gronwald, H.; Grube, M.; Harnett, P. R.; Harris, H. R.; Hartkopf, A. D.; Hartmann, A.; Hein, A.; Hendley, J.; Hernandez, B. Y.; Huang, Y. J.; Jakubowska, A.; Jimenez-Linan, M ...; Jones, M. E.; Kennedy, C. J.; Kluz, T.; Koziak, J. M.; Lesnock, J.; Lester, J.; Lubinski, J.; Longacre, T. A.; Lycke, Maria; Mateoiu, Constan ...; McCauley, B. M.; McGuire, V.; Ney, B.; Olawaiye, A.; Orsulic, S.; Osorio, A.; Paz-Ares, L.; Cajal, T. R. Y.; Rothstein, J. H.; Ruebner, M.; Schoemaker, M. J ...; Shah, M. T.; Sharma, R.; Sherman, M. E.; Shvetsov, Y. B.; Singh, N.; Steed, H.; Storr, S. J.; Talhouk, A.; Traficante, N.; Wang, C.; Whittemore, A. S ...; Widschwendter, M ...; Wilkens, L. R.; Winham, S. J.; Benitez, J.; Berchuck, A.; Bowtell, D. D.; dos Reis, F. J. ...; Campbell, I.; Cook, L. S.; DeFazio, A.; Doherty, J. A.; Fasching, P. A.; Fortner, R. T.; Garcia, M. J.; Goodman, M. T.; Goode, E. L.; Gronwald, J.; Huntsman, D. G.; Karlan, B. Y.; Kelemen, L. E.; Kommoss, S.; Le, N. D.; Martin, S. G.; Menon, U.; Modugno, F.; Pharoah, P. D. P ...; Schildkraut, J. ...; Sieh, W.; Staebler, A.; Sundfeldt, Karin ...; Swerdlow, A. J.; Ramus, S. J.; Brenton, J. D.; Aocs Grp, Aocs G ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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