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Association of Gout...
Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout
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- Sumpter, N. A. (author)
- University of Alabama,University of Nottingham
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Takei, R. (author)
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- Cadzow, M. (author)
- University of Otago
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- Topless, R. K. G. (author)
- University of Otago
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- Phipps-Green, A. J. (author)
- University of Otago
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Murphy, R. (author)
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de Zoysa, J. (author)
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Watson, H. (author)
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Qasim, M. (author)
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- Lupi, A. S. (author)
- Michigan State University,Lausanne University Hospital
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- Abhishek, A. (author)
- University of Medicine and Pharmacy, Cluj-Napoca
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- Andres, M. (author)
- Miguel Hernández University of Elche
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- Crisan, T. O. (author)
- University of Medicine and Pharmacy, Cluj-Napoca
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- Doherty, M. (author)
- University of Nottingham
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- Jacobsson, Lennart T. H., 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy
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- Janssen, M. (author)
- Viecuri Medical Centre Of Northern Limburg,University of Otago
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- Jansen, T. L. (author)
- Viecuri Medical Centre Of Northern Limburg
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Joosten, L. A. B. (author)
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- Kapetanovic, Meliha (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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Liote, F. (author)
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- Matsuo, H. (author)
- National Defense Medical College
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- McCarthy, G. M. (author)
- Mater Misericordiae University Hospital
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- Perez-Ruiz, F. (author)
- Biocruces Bizkaia Health Research Institute
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- Riches, P. (author)
- University of Edinburgh
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- Richette, P. (author)
- Université Paris Cité
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- Roddy, E. (author)
- Keele University
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- Stiburkova, B. (author)
- General University Hospital in Prague
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So, A. (author)
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- Tausche, A. K. (author)
- University Clinic Carl Gustav Carus at the TU Dresden
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- Torres, R. J. (author)
- University Hospital La Paz
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- Uhlig, T. (author)
- Diakonhjemmet Hospital
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Major, T. J. (author)
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Stamp, L. K. (author)
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Dalbeth, N. (author)
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- Choi, H. K. (author)
- Massachusetts General Hospital
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- Vazquez, A. I. (author)
- Michigan State University
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Leask, M. P. (author)
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Reynolds, R. J. (author)
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- Merriman, T. R. (author)
- University of Alabama
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(creator_code:org_t)
- 2023-03-25
- 2023
- English.
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In: Arthritis & Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 75:5, s. 816-825
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Objective. To determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and West Polynesian men and women with gout. Methods. A 19-variant gout PRS was produced in 7 European gout cohorts (N = 4,016), 2 East Polynesian gout cohorts (N = 682), and 1 West Polynesian gout cohort (N = 490). Sex-stratified regression models were used to estimate the relationship between the PRS and age at gout onset and tophaceous disease. Results. The PRS was associated with earlier age at gout onset in men (beta = -3.61 in years per unit PRS [95% confidence interval (95% CI) -4.32, -2.90] in European men; beta = -6.35 [95% CI -8.91, -3.80] in East Polynesian men; beta = -3.51 [95% CI -5.46, -1.57] in West Polynesian men) but not in women (beta = 0.07 [95% CI -2.32, 2.45] in European women; beta = 0.20 [95% CI -7.21, 7.62] in East Polynesian women; beta -3.33 [95% CI -9.28, 2.62] in West Polynesian women). The PRS showed a positive association with tophaceous disease in men (odds ratio [OR] for the association 1.15 [95% CI 1.00, 1.31] in European men; OR 2.60 [95% CI 1.66, 4.06] in East Polynesian men; OR 1.53 [95% CI 1.07, 2.19] in West Polynesian men) but not in women (OR for the association 0.68 [95% CI 0.42, 1.10] in European women; OR 1.45 [95% CI 0.39, 5.36] in East Polynesian women). The PRS association with age at gout onset was robust to the removal of ABCG2 variants from the PRS in European and East Polynesian men (beta = -2.42 [95% CI -3.37, -1.46] and beta = -6.80 [95% CI -10.06, -3.55], respectively) but not in West Polynesian men (beta = -1.79 [95% CI -4.74, 1.16]). Conclusion. Genetic risk variants for gout also harbor risk for earlier age at gout onset and tophaceous disease in European and Polynesian men. Our findings suggest that earlier gout onset involves the accumulation of gout risk alleles in men but perhaps not in women, and that this genetic risk is shared across multiple ancestral groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sumpter, N. A.
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Takei, R.
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Cadzow, M.
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Topless, R. K. G ...
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Phipps-Green, A. ...
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Murphy, R.
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show more...
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de Zoysa, J.
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Watson, H.
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Qasim, M.
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Lupi, A. S.
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Abhishek, A.
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Andres, M.
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Crisan, T. O.
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Doherty, M.
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Jacobsson, Lenna ...
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Janssen, M.
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Jansen, T. L.
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Joosten, L. A. B ...
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Kapetanovic, Mel ...
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Liote, F.
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Matsuo, H.
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McCarthy, G. M.
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Perez-Ruiz, F.
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Riches, P.
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Richette, P.
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Roddy, E.
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Stiburkova, B.
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So, A.
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Tausche, A. K.
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Torres, R. J.
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Uhlig, T.
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Major, T. J.
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Stamp, L. K.
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Dalbeth, N.
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Choi, H. K.
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Vazquez, A. I.
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Leask, M. P.
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Reynolds, R. J.
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Merriman, T. R.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Arthritis & Rheu ...
- By the university
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University of Gothenburg
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Lund University