Search: WFRF:(Ioannidou Athina) >
Birth order, sibshi...
Birth order, sibship size, and risk of atopic dermatitis, food allergy, and atopy: A systematic review and meta-analysis
-
- Lisik, Daniil (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
-
- Ermis, Özuygur, 1991 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
-
- Ioannidou, Athina (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
-
show more...
-
Milani, Gregorio Paolo (author)
-
- Nyassi, Sungkutu (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
-
Spolidoro, Giulia Carla Immacolata (author)
-
- Kankaanranta, Hannu, 1967 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
-
- Goksör, Emma, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
- Wennergren, Göran, 1947 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
- Nwaru, Bright I, 1978 (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Krefting Research Centre
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Clinical and translational allergy. - 2045-7022. ; 13:6
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Atopic dermatitis and food allergy are two frequently concomitant manifestations of the presence of atopy. A substantial number of studies have been published on the association of birth order and sibship size (number of siblings) with atopic dermatitis, food allergy, and atopy. The present work is the first systematic synthesis of the existing literature on this topic.Fifteen databases were searched. Screening, data extraction, and quality assessment were performed by independent pairs. Comparable numerical data were statistically synthesized using random-effects robust variance estimation.In total, 114 studies were included out of 8819 papers obtained from database searches. Birth order ≥2 versus 1 was associated with lower risk of ever atopic dermatitis (pooled risk ratio [RR] 0.91, 95% CI 0.84-0.98), current food allergy (RR 0.77, 95% CI 0.66-0.90), and positive skin prick test (SPT) to common aeroallergens (RR 0.86, 95% CI 0.77-0.97). Sibship size ≥2 versus 1 was associated with decreased risk of current atopic dermatitis (RR 0.90, 95% CI 0.83-0.98), ever atopic dermatitis (RR 0.92, 95% CI 0.86-0.97), and positive SPT to common aeroallergens (RR 0.88, 95% CI 0.83-0.92). No putative associations were seen regarding atopy assessed through allergen-specific immunoglobulin E with common allergens.The presence of siblings and being second-born or later may decrease the lifetime risk of atopic dermatitis and food allergy, albeit marginally. Similar association was seen with SPT sensitization. However, significant protection was not found for IgE sensitization.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lisik, Daniil
-
Ermis, Özuygur, ...
-
Ioannidou, Athin ...
-
Milani, Gregorio ...
-
Nyassi, Sungkutu
-
Spolidoro, Giuli ...
-
show more...
-
Kankaanranta, Ha ...
-
Goksör, Emma, 19 ...
-
Wennergren, Göra ...
-
Nwaru, Bright I, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
- Articles in the publication
-
Clinical and tra ...
- By the university
-
University of Gothenburg