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Healthy Nordic diet...
Healthy Nordic diet and associations with plasma concentrations of metabolites in the choline oxidation pathway: a cross-sectional study from Northern Sweden
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- Hesselink, André, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden
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- Winkvist, Anna, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Umeå universitet,Umeå University,University of Gothenburg,Avdelningen för hållbar hälsa,Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden
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- Lindahl, Bernt (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Ueland, P. M. (författare)
- Universitetet i Bergen,University of Bergen,Department of Clinical Science, University of Bergen, Bergen, Norway; Bevital AS, Bergen, Norway
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- Schneede, Jørn (författare)
- Umeå universitet,Institutionen för farmakologi och klinisk neurovetenskap
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- Johansson, Ingegerd (författare)
- Umeå universitet,Institutionen för odontologi
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- Karlsson, Therese, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden; Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden
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(creator_code:org_t)
- BioMed Central (BMC), 2023
- 2023
- Engelska.
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Ingår i: Nutrition Journal. - : BioMed Central (BMC). - 1475-2891. ; 22:1
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Abstract
Ämnesord
Stäng
- BackgroundThe choline oxidation pathway and metabolites involved have been linked to diseases including cardiovascular disease, type 2 diabetes and cancer. A healthy Nordic diet is a recently defined dietary pattern associated with decreased risk for these diseases. Our aim was to explore associations between adherence to a healthy Nordic diet and plasma concentrations of metabolites of the choline oxidation pathway.MethodsThe Healthy Nordic Food Index (HNFI) and Baltic Sea Diet Score (BSDS) were applied to cross-sectional data (n = 969) from the Vasterbotten Intervention Programme in Northern Sweden to score adherence to a healthy Nordic diet. Data included responses to a dietary questionnaire and blood sample analyses (1991-2008). Associations of diet scores with plasma concentrations of metabolites of the choline oxidation pathway and total homocysteine (tHcy), seven metabolites in total, were evaluated with linear regression, adjusting for age, BMI, education and physical activity.ResultsHNFI scores showed linear relationships with plasma choline (beta = 0.11), betaine (beta = 0.46), serine (beta = 0.98) and tHcy (beta = - 0.38), and BSDS scores with betaine (beta = 0.13) and tHcy (beta = - 0.13); unstandardized beta coefficients, all significant at P < 0.05. The regression models predicted changes in plasma metabolite concentrations (+/- 1 SD changes in diet score) in the range of 1-5% for choline, betaine, serine and tHcy. No other statistically significant associations were observed.ConclusionsA healthy Nordic diet was associated with plasma concentrations of several metabolites of the choline oxidation pathway. Although relationships were statistically significant, effect sizes were moderate. Further research is warranted to explore the underlying mechanisms and associations with health outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Healthy Nordic diet
- Healthy Nordic Food Index
- Baltic Sea Diet Score
- One-carbon metabolism
- Choline oxidation pathway
- Vasterbotten
- Intervention Programme
- one-carbon metabolism
- homocysteine concentration
- risk-factors
- amino-acids
- elderly-men
- b vitamins
- biomarkers
- betaine
- serum
- population
- Nutrition & Dietetics
- Choline oxidation pathway
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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