Neurodevelopmental and other psychiatric disorders in 22q11.2 deletion syndrome from childhood to adult age: Prospective longitudinal study of 100 individuals

Wallin, LenaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology (författare)

The 22q11.2 deletion syndrome (22q11.2DS), affects physical as well as cognitive and emotional functioning with increased risk for psychiatric and behavioral problems. This longitudinal study of 79 individuals (18-50 years) with 22q11.2DS investigated neurodevelopmental (NDD) and psychiatric disorders in adulthood, evaluated the stability of childhood diagnoses over time, and examined associations between clinical characteristics in childhood/adolescence and diagnostic outcome in adult age. Examination using validated instruments for cognitive, psychiatric, and global functional problems in the context of an in-depth clinical evaluation found adult age stability of NDD diagnoses made in childhood, however, rates increased at follow-up. Rates of anxiety, mood, and psychotic disorders were high, with a majority meeting diagnostic criteria for one or more psychiatric disorder. The rate of psychotic disorders was much lower compared to many other studies. Variability in functioning at follow-up was primarily associated with intellectual ability at T1. The findings obtained highlight the increased risk of NDD and psychiatric problems and of cognitive impairment and reduced levels of global functioning over time. Results emphasize the importance of clinical follow-up to enable appropriate support for the promotion of optimal health along with a need for future research on effective interventions and treatment strategies.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
22q11
2 deletion syndrome
follow up
neurodevelopmental
psychiatric
phenotype
behavior
autism spectrum disorder
risk-factors
asperger-syndrome
total
population
screening scale
psychosis
prevalence
epidemiology
children
schizophrenia
Genetics & Heredity

Gillberg, Christopher,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Gillbergcentrum,Institute of Neuroscience and Physiology,Gillberg Neuropsychiatry Centre(Swepub:gu)xgilch (författare)
Fernell, Elisabeth,1948Gothenburg University,Göteborgs universitet,Gillbergcentrum,Institutionen för neurovetenskap och fysiologi,Gillberg Neuropsychiatry Centre,Institute of Neuroscience and Physiology(Swepub:gu)xferne (författare)
Gillberg, I Carina,1949Gothenburg University,Göteborgs universitet,Gillbergcentrum,Institutionen för neurovetenskap och fysiologi,Gillberg Neuropsychiatry Centre,Institute of Neuroscience and Physiology(Swepub:gu)xgillc (författare)
Billstedt, Eva,1961Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Gillbergcentrum,Institute of Neuroscience and Physiology,Gillberg Neuropsychiatry Centre(Swepub:gu)xbilev (författare)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

Ingår i:American Journal of Medical Genetics Part C-Seminars in Medical Genetics193:2, s. 172-1821552-4868

Av författaren/redakt...: Wallin, Lena; Gillberg, Christ ...; Fernell, Elisabe ...; Gillberg, I Cari ...; Billstedt, Eva, ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

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