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Improved outcomes o...
Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry
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- Ljungman, P. (author)
- Karolinska Institutet
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- Tridello, G. (author)
- European Soc Blood & Marrow Transplantat EBMT Dat, Dept Med Stat & Bioinformat, Leiden, Netherlands.
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- Pinana, J. L. (author)
- Hosp Clin Univ Valencia, Hematol Dept, Valencia, Spain.;Hosp Clin Univ Valencia, Fdn Invest Hosp Clin Comun Valenciana INCL, Inst Invest Sanit, Valencia, Spain.
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- Ciceri, F. (author)
- Univ Vita Salute San Raffaele, Osped San Raffaele, IRCCS, Milan, Italy.
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- Sengeloev, H. (author)
- Copenhagen Univ Hosp, Dept Hematol, Copenhagen, Denmark.
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- Kulagin, A. (author)
- Pavlov Univ, Raisa Mem RM Gorbacheva Res Inst, St Petersburg, Russia.
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- Mielke, S. (author)
- Karolinska Institutet
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- Yegin, Z. A. (author)
- Gazi Univ, Dept Hematol, Fac Med, Ankara, Turkiye.
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- Collin, M. (author)
- Newcastle Biomed Res Ctr, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.;Newcastle Biomed Res Ctr, Natl Inst Hlth & Care Res NIHR, Newcastle Upon Tyne, Tyne & Wear, England.
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- Einarsdottir, Sigrun (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.;Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Internal Med, Gothenburg, Sweden.
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- Lepretre, S. D. (author)
- Hop Lyon Sud, Serv Hematol, Lyon, France.
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- Maertens, J. (author)
- Univ Hosp Gasthuisberg, Dept Hematol, Leuven, Belgium.
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- Campos, A. (author)
- Inst Portugues Oncol Porto, Marrow Transplant Dept, Porto, Portugal.
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- Metafuni, E. (author)
- Fdn Policlin Univ Agostino Gemelli Ist Ricovero &, Dipartimento Diagnost Immagini Radioterapia Oncol, Rome, Italy.
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- Pichler, H. (author)
- Med Univ Vienna, St Anna Childrens Hosp, Dept Pediat & Adolescent Med, Vienna, Austria.
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- Folber, F. (author)
- Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic.;Masaryk Univ, Dept Internal Med Hematol & Oncol, Brno, Czech Republic.
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- Solano, C. (author)
- European Soc Blood & Marrow Transplantat EBMT Dat, Dept Med Stat & Bioinformat, Leiden, Netherlands.
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- Nicholson, E. (author)
- Royal Marsden Hosp, Haematol Oncol Unit, London, England.
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- Ynksel, M. K. (author)
- Ankara Univ, Dept Hematol, Fac Med, Ankara, Turkiye.,Univ Genoa, Div Infect Dis, Genoa, Italy.;Osped Policlin San Martino, Genoa, Italy.
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- Carlson, Kristina (author)
- Uppsala universitet,Hematologi
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- Aguado, B. (author)
- Hosp Univ Princesa, Dept Hematol, Madrid, Spain.
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- Besley, C. (author)
- Univ Hosp Bristol & Weston Natl Hlth Serv NHS Fdn, Bristol, Avon, England.
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- Byrne, J. (author)
- Nottingham Univ Hosp, Dept Haematol, Nottingham, England.
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- Heras, I. (author)
- Univ Murcia, Hosp Univ Morales Meseguer, Dept Hematol, Inst Murciano Invest Biosanit IMIB Arrixaca, Murcia, Spain.
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- Dignan, F. (author)
- Manchester Royal Infirm, Clin Haematol Dept, Manchester, England.
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- Kroger, N. (author)
- Univ Hosp Eppendorf, Dept Stem Cell Transplantat, Hamburg, Germany.
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- Robin, C. (author)
- Henri Mondor Hosp, AP HP, Dept Hematol, Creteil, France.
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- Khan, A. (author)
- Leeds Teaching Hosp NHS Trust, Dept Haematol, Leeds, W Yorkshire, England.
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- Lenhoff, S. (author)
- Skanes Univ Hosp, Dept Hematol, Lund, Sweden.
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- Grassi, A. (author)
- Azienda Sociosanit Terr ASST Papa Giovanni XXIII, Bone Marrow Transplantat Unit, Bergamo, Italy.
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- Dobsinska, V. (author)
- Comenius Univ, Natl Inst Childrens Dis, Dept Pediat Hematol & Oncol, Bratislava, Slovakia.
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- Miranda, N. (author)
- Inst Portugues Oncol Francisco Gentil, Dept Haematol, Lisbon, Portugal.
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- Jimenez, M. J. (author)
- Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol ICO, Dept Clin Haematol, Badalona, Spain.
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- Yonal-Hindilerden, I. (author)
- Istanbul Univ, Istanbul Med Fac, Adult Hematopoiet Stem Cell Transplant Ctr, Istanbul, Turkiye.
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- Wilson, K. (author)
- Univ Cardiff, Blood & Bone Marrow Transplantat Dept, Cardiff, Wales.
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- Averbuch, D. (author)
- Hebrew Univ Jerusalem, Hadassah Med Ctr, Pediat Infect Dis Unit, Jerusalem, Israel.;Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel.
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- Cesaro, S. (author)
- Azienda Osped Univ Integrata, Pediat Hematol Oncol, Verona, Italy.
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- Xhaard, A. (author)
- Hop St Louis, Hematol Transplantat Unit, Dept Hematol, Paris, France.
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- Knelange, N. (author)
- European Soc Blood & Marrow Transplantat EBMT Dat, European Soc Blood & Marrow Transplantat EBMT, Leiden Study Unit, Leiden, Netherlands.
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- Styczynski, J. (author)
- Nicolaus Copernicus Univ Torun, Dept Pediat Hematol & Oncol, Coll Med, Bydgoszcz, Poland.
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Mikulska, M. (author)
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- de la Camara, R. (author)
- Hosp Univ Princesa, Dept Hematol, Madrid, Spain.
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Karolinska Institutet European Soc Blood & Marrow Transplantat EBMT Dat, Dept Med Stat & Bioinformat, Leiden, Netherlands (creator_code:org_t)
- 2023-03-07
- 2023
- English.
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In: FRONTIERS IN IMMUNOLOGY. - : Frontiers Media SA. - 1664-3224. ; 14
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Subject headings
Close
- IntroductionCOVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. MethodsThis study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic. ResultsThe median age was 50.3 years (min - max; 1.0 - 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min - max; 0.0 - 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 - 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 - 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022. DiscussionAlthough the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- COVID-19
- allogeneic
- stem cell transplantation
- CMV
- risk factors
- therapy
- Immunology
- COVID-19
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ljungman, P.
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Tridello, G.
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Pinana, J. L.
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Ciceri, F.
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Sengeloev, H.
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Kulagin, A.
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show more...
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Mielke, S.
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Yegin, Z. A.
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Collin, M.
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Einarsdottir, Si ...
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Lepretre, S. D.
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Maertens, J.
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Campos, A.
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Metafuni, E.
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Pichler, H.
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Folber, F.
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Solano, C.
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Nicholson, E.
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Ynksel, M. K.
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Carlson, Kristin ...
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Aguado, B.
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Besley, C.
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Byrne, J.
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Heras, I.
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Dignan, F.
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Kroger, N.
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Robin, C.
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Khan, A.
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Lenhoff, S.
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Grassi, A.
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Dobsinska, V.
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Miranda, N.
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Jimenez, M. J.
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Yonal-Hindilerde ...
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Wilson, K.
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Averbuch, D.
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Cesaro, S.
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Xhaard, A.
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Knelange, N.
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Styczynski, J.
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Mikulska, M.
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de la Camara, R.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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FRONTIERS IN IMM ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet