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Longitudinal blood ...
Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease
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Yakoub, Y. (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Strikwerda-Brown, C. (author)
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- Montoliu-Gaya, Laia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Kac, Przemyslaw R. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Gonzalez-Ortiz, Fernando (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Gallego-Rudolf, J. (author)
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Meyer, P. F. (author)
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St-Onge, F. (author)
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- Schöll, Michael, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Soucy, J. P. (author)
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Breitner, J. C. S. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Poirier, J. (author)
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Villeneuve, S. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Alzheimers & Dementia. - 1552-5260. ; 19:12, s. 5620-5631
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: Plasma biomarkers are altered years prior to Alzheimer's disease (AD) clinical onset. Methods: We measured longitudinal changes in plasma amyloid-beta (A beta)(42/40) ratio, pTau181, pTau231, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) in a cohort of older adults at risk of AD (n = 373 total, n = 229 with A beta and tau positron emission tomography [PET] scans) considering genetic and demographic factors as possible modifiers of these markers' progression. Results: A beta(42/40) ratio concentrations decreased, while NfL and GFAP values increased over the 4-year follow-up. Apolipoprotein E (APOE) epsilon 4 carriers showed faster increase in plasma pTau181 than non-carriers. Older individuals showed a faster increase in plasma NfL, and females showed a faster increase in plasma GFAP values. In the PET subsample, individuals both A beta-PET and tau-PET positive showed faster plasma pTau181 and GFAP increase compared to PET-negative individuals. Discussion: Plasma markers can track biological change over time, with plasma pTau181 and GFAP markers showing longitudinal change in individuals with preclinical AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- A beta
- biomarker
- PET
- plasma
- pTau
- association workgroups
- diagnostic guidelines
- national institute
- amyloid-beta
- tau
- pet
- recommendations
- performance
- plaques
- tangles
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Yakoub, Y.
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Ashton, Nicholas ...
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Strikwerda-Brown ...
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Montoliu-Gaya, L ...
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Karikari, Thomas
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Kac, Przemyslaw ...
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show more...
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Gonzalez-Ortiz, ...
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Gallego-Rudolf, ...
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Meyer, P. F.
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St-Onge, F.
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Schöll, Michael, ...
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Soucy, J. P.
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Breitner, J. C. ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Poirier, J.
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Villeneuve, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg