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Longitudinal blood ...
Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/327458
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https://gup.ub.gu.se/publication/327458URI
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https://doi.org/10.1002/alz.13318DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Introduction: Plasma biomarkers are altered years prior to Alzheimer's disease (AD) clinical onset. Methods: We measured longitudinal changes in plasma amyloid-beta (A beta)(42/40) ratio, pTau181, pTau231, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) in a cohort of older adults at risk of AD (n = 373 total, n = 229 with A beta and tau positron emission tomography [PET] scans) considering genetic and demographic factors as possible modifiers of these markers' progression. Results: A beta(42/40) ratio concentrations decreased, while NfL and GFAP values increased over the 4-year follow-up. Apolipoprotein E (APOE) epsilon 4 carriers showed faster increase in plasma pTau181 than non-carriers. Older individuals showed a faster increase in plasma NfL, and females showed a faster increase in plasma GFAP values. In the PET subsample, individuals both A beta-PET and tau-PET positive showed faster plasma pTau181 and GFAP increase compared to PET-negative individuals. Discussion: Plasma markers can track biological change over time, with plasma pTau181 and GFAP markers showing longitudinal change in individuals with preclinical AD.
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Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn
(author)
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Strikwerda-Brown, C.
(author)
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Montoliu-Gaya, LaiaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xmonla
(author)
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Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit
(author)
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Kac, Przemyslaw R.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkacpv
(author)
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Gonzalez-Ortiz, FernandoGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xgonfe
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Gallego-Rudolf, J.
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Meyer, P. F.
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St-Onge, F.
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Schöll, Michael,1980Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xschom
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Soucy, J. P.
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Breitner, J. C. S.
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Poirier, J.
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Villeneuve, S.
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Alzheimers & Dementia19:12, s. 5620-56311552-5260
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Yakoub, Y.
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Ashton, Nicholas ...
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Strikwerda-Brown ...
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Montoliu-Gaya, L ...
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Karikari, Thomas
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Kac, Przemyslaw ...
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Gonzalez-Ortiz, ...
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Gallego-Rudolf, ...
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Meyer, P. F.
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St-Onge, F.
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Schöll, Michael, ...
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Soucy, J. P.
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Breitner, J. C. ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Poirier, J.
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Villeneuve, S.
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- MEDICAL AND HEALTH SCIENCES
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and Neurosciences
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Alzheimers & Dem ...
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University of Gothenburg