APOE and immunity: Research highlights

INTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODSThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTSDuring the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor alpha [TNF alpha]). DISCUSSIONThis manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Alzheimer's disease
amyloid beta
APOE
astrocytes
biomarkers
dementia
inflammation
microglia
neurodegeneration
neuroglia
neuroinflammation
tau
TREM2
Alzheimer's disease

Barnum, C. J. (author)
Batista, A. F. (author)
Bradshaw, E. M. (author)
Brickman, A. M. (author)
Bu, G. J. (author)
Dennison, J. (author)
Gearon, M. D. (author)
Goate, A. M. (author)
Haass, C. (author)
Heneka, M. T. (author)
Hu, W. T. (author)
Huggins, L. K. L. (author)
Jones, N. S. (author)
Koldamova, R. (author)
Lemere, C. A. (author)
Liddelow, S. A. (author)
Marcora, E. (author)
Marsh, S. E. (author)
Nielsen, Henrietta M.,1979-Stockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)hniel (author)
Petersen, K. K. (author)
Petersen, M. (author)
Pina-Escudero, S. D. (author)
Qiu, W. Q. (author)
Quiroz, Y. T. (author)
Reiman, E. (author)
Sexton, C. (author)
Tansey, M. G. (author)
Julia, T. C. W. (author)
Teunissen, C. E. (author)
Tijms, B. M. (author)
van der Kant, R. (author)
Wallings, R. (author)
Weninger, S. C. (author)
Wharton, W. (author)
Wilcock, D. M. (author)
Wishard, T. J. (author)
Worley, S. L. (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Carrillo, M. C. (author)
Stockholms universitetInstitutionen för biokemi och biofysik (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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