Magnetic resonance imaging of the knee for chronological age estimation-a systematic review

IntroductionRadiographs of the hand and teeth are frequently used for medical age assessment, as skeletal and dental maturation correlates with chronological age. These methods have been criticized for their lack of precision, and magnetic resonance imaging (MRI) of the knee has been proposed as a more accurate method. The aim of this systematic review is to explore the scientific and statistical evidence for medical age estimation based on skeletal maturation as assessed by MRI of the knee.Materials and methodsA systematic review was conducted that included studies published before April 2021 on living individuals between 8 and 30 years old, with presumptively healthy knees for whom the ossification stages had been evaluated using MRI. The correlation between "mature knee" and chronological age and the risk of misclassifying a child as an adult and vice versa was calculated.ResultsWe found a considerable heterogeneity in the published studies -in terms of study population, MRI protocols, and grading systems used. There is a wide variation in the correlation between maturation stage and chronological age.ConclusionData from published literature is deemed too heterogenous to support the use of MRI of the knee for chronological age determination. Further, it is not possible to assess the sensitivity, specificity, negative predictive value, or positive predictive value for the ability of MRI to determine whether a person is over or under 18 years old.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Systematic review
Magnetic resonance imaging
Knee joint
Age
determination by skeleton
Predictive value of tests
mri
Radiology
Nuclear Medicine & Medical Imaging

Adolfsson, J.Karolinska Institutet (författare)
Forsberg, L.Karolinska Institutet (författare)
Bring, J. (författare)
Dahlgren, Jovanna,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xdajov (författare)
Domeij, H. (författare)
Gornitzki, C. (författare)
Wernersson, E. (författare)
Odeberg, J. (författare)
Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik (creator_code:org_t)

Av författaren/redakt...: Muller, L. S. O.; Adolfsson, J.; Forsberg, L.; Bring, J.; Dahlgren, Jovann ...; Domeij, H.; visa fler...; Gornitzki, C.; Wernersson, E.; Odeberg, J.; visa färre...

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