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Circulating microRN...
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Swolin-Eide, Diana,1968Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
(författare)
Circulating microRNAs in young individuals with long-duration type 1 diabetes in comparison with healthy controls.
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:gup.ub.gu.se/327672
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https://gup.ub.gu.se/publication/327672URI
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https://doi.org/10.1038/s41598-023-38615-7DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197559URI
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MicroRNAs (miRNAs) are short non-coding RNAs that are involved in post-transcriptional control of gene expression and might be used as biomarkers for diabetes-related complications. The aim of this case-control study was to explore potential differences in circulating miRNAs in young individuals with long-duration type 1 diabetes (T1D) compared to healthy controls, and how identified miRNAs are expressed across different tissues. Twelve adolescents, age 15.0-17.9years, with T1D duration of more than 8years (mean 11.1years), were enrolled from the Swedish diabetes quality registry. An age-matched control group was recruited. Circulating miRNAs (n=187) were analyzed by quantitative PCR. We observed that 27 miRNAs were upregulated and one was downregulated in T1D. Six of these miRNAs were tissue-enriched (blood cells, gastrointestinal, nerve, and thyroid tissues). Six miRNAs with the largest difference in plasma, five up-regulated (hsa-miR-101-3p, hsa-miR-135a-5p, hsa-miR-143-3p, hsa-miR-223-3p and hsa-miR-410-3p (novel for T1D)) and one down-regulated (hsa-miR-495-3p), with P-values below 0.01, were selected for further in-silico analyses. AKT1, VEGFA and IGF-1 were identified as common targets. In conclusion, 28 of the investigated miRNAs were differently regulated in long-duration T1D in comparison with controls. Several associations with cancer were found for the six miRNAs with the largest difference in plasma.
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Forsander, Gun,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden(Swepub:gu)xfgunj
(författare)
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Pundziute Lyckå, AusteGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
(författare)
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Novak, DanielGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden(Swepub:gu)xnovda
(författare)
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Grillari, JohannesRes Ctr Cooperat AUVA, Austria; Univ Nat Resources & Life Sci, Austria; Austrian Cluster Tissue Regenerat, Austria
(författare)
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Diendorfer, Andreas BTAmiRNA GmbH, Austria
(författare)
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Hackl, MatthiasTAmiRNA GmbH, Austria
(författare)
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Magnusson, PerLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)perma28
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik
(creator_code:org_t)
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Ingår i:Scientific reports: NATURE PORTFOLIO13:12045-2322
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