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High Exposure to Pe...
High Exposure to Perfluoroalkyl Substances and Antibody Responses to SARS-CoV-2 mRNA Vaccine-an Observational Study in Adults from Ronneby, Sweden.
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- Andersson, Axel G (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Lundgren, Anna, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Sahlgrenska University Hospital
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- Xu, Yiyi (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Nielsen, Christel (author)
- Lund University,Lunds universitet,Epidemiologi,Forskargrupper vid Lunds universitet,Epidemiology,Lund University Research Groups,University of Southern Denmark
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- Lindh, Christian H (author)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Pineda, Daniela (author)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Other operations, LTH,Faculty of Engineering, LTH,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Applied Mass Spectrometry in Environmental Medicine
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- Cederlund, Julia (author)
- Region Blekinge
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- Pataridou, Elisavet (author)
- Region Blekinge
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- Søgaard Tøttenborg, Sandra (author)
- University of Copenhagen
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- Ugelvig Petersen, Kajsa (author)
- Bispebjerg Hospital
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- Fletcher, Tony (author)
- London School of Hygiene and Tropical Medicine
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- Lagging, Martin, 1965 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Bemark, Mats, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Sahlgrenska University Hospital
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- Jakobsson, Kristina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska University Hospital
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- Li, Ying (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Environmental health perspectives. - 1552-9924. ; 131:8
- Related links:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Per- and polyfluoroalkyl substances (PFAS) are widely used, environmentally ubiquitous, and stable chemicals that have been associated with lower vaccine-induced antibody responses in children; however, data on adults are limited. The drinking water from one of the two waterworks in Ronneby, Sweden, was heavily contaminated for decades with PFAS from firefighting foams, primarily perfluorohexane sulfonic acid and perfluorooctanesulfonic acid (PFOS). Vaccination against SARS-CoV-2 offered a unique opportunity to investigate antibody responses to primary vaccination in adults who had been exposed to PFAS.Our objective was to evaluate associations between PFAS, across a wide range of exposure levels, and antibody responses in adults 5 wk and 6 months after a two-dose vaccination regime against SARS-CoV-2.Adults age 20-60 y from Ronneby (n=309, median PFOS serum level 47ng/mL, fifth to 95th percentile 4-213ng/mL) and a group with background exposure (n=47, median PFOS serum level 4ng/mL) received two doses of the Spikevax (Moderna) mRNA vaccine. The levels of seven PFAS were measured in serum before vaccination. Serum immunoglobulin G antibodies against the SARS-CoV-2 spike antigen (S-Abs) were measured before vaccination and at 5 wk (n=350) and 6 months (n=329) after the second vaccine dose. Linear regression analyses were fitted against current, historical, and prenatal exposure to PFAS, adjusting for sex, age, and smoking, excluding individuals with previous SARS-CoV-2-infection.PFAS exposure, regardless of how it was estimated, was not negatively associated with antibody levels 5 wk [current PFOS: -0.5% S-Abs/PFOS interquartile range (IQR); 95% confidence interval (CI): -8, 7] or 6 months (current PFOS: 3% S-Abs/PFOS IQR; 95% CI: -6, 12) after COVID-19 vaccination.Following a strict study protocol, rigorous study design, and few dropouts, we found no indication that PFAS exposure negatively affected antibody responses to COVID-19 mRNA vaccination for up to 6 months after vaccination. https://doi.org/10.1289/EHP11847.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Child
- Humans
- Adult
- Young Adult
- Middle Aged
- COVID-19 Vaccines
- SARS-CoV-2
- Sweden
- epidemiology
- Antibody Formation
- COVID-19
- prevention & control
- Alkanesulfonic Acids
- Vaccines
- Fluorocarbons
- Sweden/epidemiology
- COVID-19/prevention & control
Publication and Content Type
- ref (subject category)
- art (subject category)
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Andersson, Axel ...
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Lundgren, Anna, ...
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Xu, Yiyi
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Nielsen, Christe ...
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Lindh, Christian ...
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Pineda, Daniela
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Cederlund, Julia
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Pataridou, Elisa ...
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Søgaard Tøttenbo ...
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Ugelvig Petersen ...
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Fletcher, Tony
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Lagging, Martin, ...
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Bemark, Mats, 19 ...
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Jakobsson, Krist ...
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Li, Ying
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