Search: id:"swepub:oai:gup.ub.gu.se/327975" >
Cerebral venous sin...
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van de Munckhof, A.
(author)
Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/327975
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https://gup.ub.gu.se/publication/327975URI
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https://doi.org/10.1177/17474930231182901DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs. Aims: We studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs. Methods: We report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs). Results: Until August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey). Of these 63, 32 (51%) met the VITT criteria, compared to 103 of 165 (62%) from HICs. Only 5 of the 32 (16%) CVST-VITT cases from MICs had definite VITT, mostly because anti-platelet factor 4 antibodies were often not tested. The median age was 26 (interquartile range [IQR] 20-37) versus 47 (IQR 32-58) years, and the proportion of women was 25 of 32 (78%) versus 77 of 103 (75%) in MICs versus HICs, respectively. Patients from MICs were diagnosed later than patients from HICs (1/32 [3%] vs. 65/103 [63%] diagnosed before May 2021). Clinical manifestations, including intracranial hemorrhage, were largely similar as was intravenous immunoglobulin use. In-hospital mortality was lower in MICs (7/31 [23%, 95% confidence interval (CI) 11-40]) than in HICs (44/102 [43%, 95% CI 34-53], p = 0.039). Conclusions: The number of CVST-VITT cases reported from LMICs was small despite the widespread use of adenoviral vaccines. Clinical manifestations and treatment of CVST-VITT cases were largely similar in MICs and HICs, while mortality was lower in patients from MICs.
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Borhani-Haghighi, A.
(author)
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Aaron, S.
(author)
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Krzywicka, K.
(author)
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van Kammen, M. S.
(author)
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Cordonnier, C.
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Kleinig, T. J.
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Field, T. S.
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Poli, S.
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Lemmens, R.
(author)
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Scutelnic, A.
(author)
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Lindgren, Erik,1993Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xliere
(author)
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Duan, J. A.
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Arslan, Y.
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van Gorp, E. C. M.
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Hovinga, J. A. K.
(author)
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Gunther, A.
(author)
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Jood, Katarina,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xjooka
(author)
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Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt
(author)
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Putaala, J.
(author)
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Heldner, M. R.
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Arnold, M.
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de Sousa, D. A.
(author)
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Wasay, M.
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Arauz, A.
(author)
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Conforto, A. B.
(author)
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Ferro, J. M.
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Coutinho, J. M.
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Johansson, Elias,1984
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
(creator_code:org_t)
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In:International Journal of Stroke18:9, s. 1112-11201747-49301747-4949
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Kleinig, T. J.
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Field, T. S.
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Duan, J. A.
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Hovinga, J. A. K ...
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Gunther, A.
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Jood, Katarina, ...
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Putaala, J.
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Heldner, M. R.
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Arnold, M.
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de Sousa, D. A.
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Wasay, M.
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Conforto, A. B.
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Ferro, J. M.
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