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Association between...
Association between high-sensitivity C-reactive protein and coronary atherosclerosis in a general middle-aged population.
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- Cederström, Sofia (författare)
- Karolinska Institutet
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- Lundman, Pia (författare)
- Karolinska Institutet
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- Alfredsson, Joakim (författare)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Hagström, Emil (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala Univ, Sweden
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- Ravn-Fischer, Annica, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Cardiology, Sahlgrenska University Hospital, Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Cardiol,Sahlgrenska Univ Hosp,Dept Mol & Clin, Gothenburg, Sweden.
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- Söderberg, Stefan (författare)
- Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umeå Univ, Heart Ctr, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Yndigegn, Troels (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärtinflammationsforskningsgrupp,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiac Inflammation Research Group,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden
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- Tornvall, Per (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Jernberg, Tomas (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Scientific reports. - : Springer Nature. - 2045-2322. ; 13:1
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Despite abundant knowledge about the relationship between inflammation and coronary atherosclerosis, it is still unknown whether systemic inflammation measured as high-sensitivity C-reactive protein (hsCRP) is associated with coronary atherosclerosis in a general population. This study aimed to examine the association between hsCRP and coronary computed tomography angiography (CCTA)-detected coronary atherosclerosis in a population-based cohort. Out of 30,154 randomly invited men and women aged 50 to 64years in the Swedish Cardiopulmonary Bioimage Study (SCAPIS), 25,408 had a technically acceptable CCTA and analysed hsCRP. Coronary atherosclerosis was defined as presence of plaque of any degree in any of 18 coronary segments. HsCRP values were categorised in four groups. Compared with hsCRP below the detection limit, elevated hsCRP (≥2.3mg/L) was weakly associated with any coronary atherosclerosis (OR 1.15, 95% CI 1.07-1.24), coronary diameter stenosis≥50% (OR 1.27, 95% CI 1.09-1.47),≥4 segments involved (OR 1.13, 95% CI 1.01-1.26 ) and severe atherosclerosis (OR 1.33, 95% CI 1.05-1.69) after adjustment for age, sex and traditional risk factors. The associations were attenuated after further adjustment for body mass index (BMI), although elevated hsCRP still associated with noncalcified plaques (OR 1.16, 95% CI 1.02-1.32), proposed to be more vulnerable. In conclusion, the additional value of hsCRP to traditional risk factors in detection of coronary atherosclerosis is low. The association to high-risk noncalcified plaques, although unlikely through a causal pathway, could explain the relationship between hsCRP and clinical coronary events in numerous studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Male
- Middle Aged
- Humans
- Female
- Coronary Artery Disease
- diagnostic imaging
- epidemiology
- C-Reactive Protein
- metabolism
- Plaque
- Atherosclerotic
- diagnostic imaging
- Atherosclerosis
- epidemiology
- Risk Factors
- Inflammation
- Coronary Angiography
- methods
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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