Timing of Primary Surgery for Cleft Palate.

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Timing of Primary Surgery for Cleft Palate.

Gamble, Carrol (författare): University of Liverpool, Liverpool, UK,Univ Liverpool, England

Persson, Christina, 1959 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sweden

Willadsen, Elisabeth (författare): University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark

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Albery, Liz (författare): Bristol Dental Hospital, Bristol, UK,Bristol Dent Hosp, England

Soegaard Andersen, Helene (författare): Copenhagen Cleft Palate Center, Copenhagen, Denmark,Copenhagen Cleft Palate Ctr, Denmark

Zattoni Antoneli, Melissa (författare): University of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil

Appelqvist, Malin (författare): Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden

Aukner, Ragnhild (författare): Statped, Oslo, Norway

Bodling, Pia (författare): Linköping University Hospital, Linköping, Sweden,Region Östergötland

Bowden, Melanie (författare): Manchester University NHS Foundation Trust, Manchester, UK,Manchester Univ NHS Fdn Trust, England

Brunnegård, Karin (författare): Umeå universitet,Logopedi,Umea Univ, Sweden

Cairns, Gillian (författare): Royal Hospital for Sick Children, Edinburgh, UK,Royal Hosp Sick Children, Scotland

Calladine, Samantha (författare): Northern and Yorkshire Regional Cleft Lip and Palate Service, Leeds, UK,Northern & Yorkshire Reg Cleft Lip & Palate Serv, England

Campbell, Linsay (författare): Cleft Care Scotland, Glasgow, UK

Clayton-Smith, Jill (författare): University of Manchester, Manchester, UK,Univ Manchester, England

Cooper, Rachael (författare): University of Liverpool, Liverpool, UK,Univ Liverpool, England

Conroy, Elizabeth (författare): University of Liverpool, Liverpool, UK,Univ Liverpool, England

El-Angbawi, Ahmed (författare): University of Manchester, Manchester, UK,Univ Manchester, England

Kildegaard Emborg, Berit (författare): Cleft Palate Center, Aarhus, Denmark,Cleft Palate Ctr, Denmark

Enfält Wikman, Josefin (författare): Norrlands University Hospital, Umeå, Sweden,Norrlands Univ Hosp, Sweden

Fitzpatrick, Beth (författare): Birmingham Children’s Hospital, Birmingham, UK,Birmingham Childrens Hosp, England

Fukushiro, Ana Paula (författare): University of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil

Guedes de Azevedo Bento Gonçalves, Cristina (författare): University of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil

Havstam, Christina (författare): Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden

Hvistendahl, Anne Katherine (författare): Statped, Oslo, Norway

Jorgensen, Line Dahl (författare): University of Copenhagen, Copenhagen, Denmark; Copenhagen Cleft Palate Center, Copenhagen, Denmark,Univ Copenhagen, Denmark; Copenhagen Cleft Palate Ctr, Denmark

Klinto, Kristina (författare): Skåne University Hospital, Malmö, Sweden,Skane Univ Hosp, Sweden

Berntsen Kvinnsland, Marit (författare): Statped, Oslo, Norway

Larham, Catriona (författare): Leeds General Infirmary, UK,Leeds Gen Infirm, England

Lemvik, Jorunn (författare): Statped, Oslo, Norway

Leturgie, Louise (författare): Cleft Palate Center, Aarhus, Denmark,Cleft Palate Ctr, Denmark

Liljerehn, Eva (författare): Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden

Lodge, Natalie (författare): Royal Hospital for Sick Children, Liverpool, UK,Royal Hosp Sick Children, Scotland

Lohmander, Anette (författare): Karolinska Institutet

McMahon, Siobhan (författare): Alder Hey Children’s NHS Foundation Trust, UK,Alder Hey Childrens NHS Fdn Trust, England

Mehendale, Felicity (författare): University of Edinburgh, Edinburgh, UK,Univ Edinburgh, Scotland

Miguel, Haline Coracine (författare): University of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil

Moe, Marianne (författare): Statped Sørøst, Oslo, Norway

Nielsen, Joan Bogh (författare): Cleft Palate Center, Aarhus, Denmark,Cleft Palate Ctr, Denmark

Nyberg, Jill (författare): Karolinska Institutet, Solna, Sweden,Karolinska Inst, Sweden

Pedersen, Nina-Helen (författare): Statped Vest, Bergen, Norway

Phippen, Ginette (författare): Salisbury District Hospital, Salisbury, UK,Salisbury Dist Hosp, England

Alvarez Piazentin-Penna, Silvia Helena (författare): University of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil

Patrick, Kathryn (författare): Manchester University NHS Foundation Trust, Manchester, UK,Manchester Univ NHS Fdn Trust, England

Pliskin, Lindsay (författare): University of Liverpool, Liverpool, UK,Univ Liverpool, England

Rigby, Lucy (författare): Royal Victoria Infirmary, Newcastle upon Tyne, UK,Royal Victoria Infirm, England

Semb, Gunvor (författare): University of Manchester, Manchester, UK,Univ Manchester, England

Southby, Lucy (författare): Oxford University Hospitals NHS Foundation Trust, Oxford, UK,Oxford Univ Hosp NHS Fdn Trust, England

Sporre, Maria (författare): Skåne University Hospital, Malmö, Sweden,Skane Univ Hosp, Sweden

Björkman Taleman, Ann-Sofie (författare): Linköping University Hospital, Linköping, Sweden,Region Östergötland

Tangstad, Jorid (författare): Statped Vest, Bergen, Norway

Trindade, Inge Elly Kiemle (författare): University of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil

Underwood, Imogen (författare): Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK,Birmingham Womens & Childrens NHS Fdn Trust, England

van Eeden, Stephanie (författare): Royal Victoria Infirmary, Newcastle upon Tyne, UK,Royal Victoria Infirm, England

Westberg, Liisi Raud (författare): Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden

Williamson, Paula Ruth (författare): University of Liverpool, Liverpool, UK,Univ Liverpool, England

Paciello Yamashita, Renata (författare): University of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil

Munro, Kevin (författare): University of Manchester, Liverpool, UK,Univ Manchester, England

Walsh, Tanya (författare): University of Manchester, Manchester, UK,Univ Manchester, England

Shaw, William (författare): University of Manchester, Manchester, UK,Univ Manchester, England

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(creator_code:org_t)

Massachusetts Medical Society, 2023
2023
Engelska.
Ingår i: The New England journal of medicine. - : Massachusetts Medical Society. - 1533-4406 .- 0028-4793. ; 389:9, s. 795-807

Relaterad länk:: https://gup.ub.gu.se...; visa fler...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Among infants with isolated cleft palate, whether primary surgery at 6 months of age is more beneficial than surgery at 12 months of age with respect to speech outcomes, hearing outcomes, dentofacial development, and safety is unknown.We randomly assigned infants with nonsyndromic isolated cleft palate, in a 1:1 ratio, to undergo standardized primary surgery at 6 months of age (6-month group) or at 12 months of age (12-month group) for closure of the cleft. Standardized assessments of quality-checked video and audio recordings at 1, 3, and 5 years of age were performed independently by speech and language therapists who were unaware of the trial-group assignments. The primary outcome was velopharyngeal insufficiency at 5 years of age, defined as a velopharyngeal composite summary score of at least 4 (scores range from 0 to 6, with higher scores indicating greater severity). Secondary outcomes included speech development, postoperative complications, hearing sensitivity, dentofacial development, and growth.We randomly assigned 558 infants at 23 centers across Europe and South America to undergo surgery at 6 months of age (281 infants) or at 12 months of age (277 infants). Speech recordings from 235 infants (83.6%) in the 6-month group and 226 (81.6%) in the 12-month group were analyzable. Insufficient velopharyngeal function at 5 years of age was observed in 21 of 235 infants (8.9%) in the 6-month group as compared with 34 of 226 (15.0%) in the 12-month group (risk ratio, 0.59; 95% confidence interval, 0.36 to 0.99; P=0.04). Postoperative complications were infrequent and similar in the 6-month and 12-month groups. Four serious adverse events were reported (three in the 6-month group and one in the 12-month group) and had resolved at follow-up.Medically fit infants who underwent primary surgery for isolated cleft palate in adequately resourced settings at 6 months of age were less likely to have velopharyngeal insufficiency at the age of 5 years than those who had surgery at 12 months of age. (Funded by the National Institute of Dental and Craniofacial Research; TOPS ClinicalTrials.gov number, NCT00993551.).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)

Nyckelord

Infant
Humans
Child
Preschool
Cleft Palate
surgery
Velopharyngeal Insufficiency
surgery
Allied Health Personnel
Europe
Postoperative Complications
epidemiology

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art (ämneskategori)

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Av författaren/redakt...: Gamble, Carrol; Persson, Christi ...; Willadsen, Elisa ...; Albery, Liz; Soegaard Anderse ...; Zattoni Antoneli ...; visa fler...; Appelqvist, Mali ...; Aukner, Ragnhild; Bodling, Pia; Bowden, Melanie; Brunnegård, Kari ...; Cairns, Gillian; Calladine, Saman ...; Campbell, Linsay; Clayton-Smith, J ...; Cooper, Rachael; Conroy, Elizabet ...; El-Angbawi, Ahme ...; Kildegaard Embor ...; Enfält Wikman, J ...; Fitzpatrick, Bet ...; Fukushiro, Ana P ...; Guedes de Azeved ...; Havstam, Christi ...; Hvistendahl, Ann ...; Jorgensen, Line ...; Klinto, Kristina; Berntsen Kvinnsl ...; Larham, Catriona; Lemvik, Jorunn; Leturgie, Louise; Liljerehn, Eva; Lodge, Natalie; Lohmander, Anett ...; McMahon, Siobhan; Mehendale, Felic ...; Miguel, Haline C ...; Moe, Marianne; Nielsen, Joan Bo ...; Nyberg, Jill; Pedersen, Nina-H ...; Phippen, Ginette; Alvarez Piazenti ...; Patrick, Kathryn; Pliskin, Lindsay; Rigby, Lucy; Semb, Gunvor; Southby, Lucy; Sporre, Maria; Björkman Taleman ...; Tangstad, Jorid; Trindade, Inge E ...; Underwood, Imoge ...; van Eeden, Steph ...; Westberg, Liisi ...; Williamson, Paul ...; Paciello Yamashi ...; Munro, Kevin; Walsh, Tanya; Shaw, William; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

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