Timing of Primary Surgery for Cleft Palate.

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Gamble, CarrolUniversity of Liverpool, Liverpool, UK,Univ Liverpool, England (författare)

Timing of Primary Surgery for Cleft Palate.

Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

Massachusetts Medical Society,2023

Nummerbeteckningar

LIBRIS-ID:oai:gup.ub.gu.se/328287
https://gup.ub.gu.se/publication/328287URI
https://doi.org/10.1056/NEJMoa2215162DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214070URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-199142URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:154116056URI

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Språk:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Funding Agencies|National Institute of Dental and Craniofacial Research [R21DE15128, U01DE018664, U01DE018837]
Among infants with isolated cleft palate, whether primary surgery at 6 months of age is more beneficial than surgery at 12 months of age with respect to speech outcomes, hearing outcomes, dentofacial development, and safety is unknown.We randomly assigned infants with nonsyndromic isolated cleft palate, in a 1:1 ratio, to undergo standardized primary surgery at 6 months of age (6-month group) or at 12 months of age (12-month group) for closure of the cleft. Standardized assessments of quality-checked video and audio recordings at 1, 3, and 5 years of age were performed independently by speech and language therapists who were unaware of the trial-group assignments. The primary outcome was velopharyngeal insufficiency at 5 years of age, defined as a velopharyngeal composite summary score of at least 4 (scores range from 0 to 6, with higher scores indicating greater severity). Secondary outcomes included speech development, postoperative complications, hearing sensitivity, dentofacial development, and growth.We randomly assigned 558 infants at 23 centers across Europe and South America to undergo surgery at 6 months of age (281 infants) or at 12 months of age (277 infants). Speech recordings from 235 infants (83.6%) in the 6-month group and 226 (81.6%) in the 12-month group were analyzable. Insufficient velopharyngeal function at 5 years of age was observed in 21 of 235 infants (8.9%) in the 6-month group as compared with 34 of 226 (15.0%) in the 12-month group (risk ratio, 0.59; 95% confidence interval, 0.36 to 0.99; P=0.04). Postoperative complications were infrequent and similar in the 6-month and 12-month groups. Four serious adverse events were reported (three in the 6-month group and one in the 12-month group) and had resolved at follow-up.Medically fit infants who underwent primary surgery for isolated cleft palate in adequately resourced settings at 6 months of age were less likely to have velopharyngeal insufficiency at the age of 5 years than those who had surgery at 12 months of age. (Funded by the National Institute of Dental and Craniofacial Research; TOPS ClinicalTrials.gov number, NCT00993551.).

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oto-rhino-laryngologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Otorhinolaryngology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Infant
Humans
Child
Preschool
Cleft Palate
surgery
Velopharyngeal Insufficiency
surgery
Allied Health Personnel
Europe
Postoperative Complications
epidemiology

Biuppslag (personer, institutioner, konferenser, titlar ...)

Persson, Christina,1959Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sweden(Swepub:gu)xperch (författare)
Willadsen, ElisabethUniversity of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark (författare)
Albery, LizBristol Dental Hospital, Bristol, UK,Bristol Dent Hosp, England (författare)
Soegaard Andersen, HeleneCopenhagen Cleft Palate Center, Copenhagen, Denmark,Copenhagen Cleft Palate Ctr, Denmark (författare)
Zattoni Antoneli, MelissaUniversity of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil (författare)
Appelqvist, MalinUppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden (författare)
Aukner, RagnhildStatped, Oslo, Norway (författare)
Bodling, PiaLinköping University Hospital, Linköping, Sweden,Region Östergötland(Swepub:liu)n/a (författare)
Bowden, MelanieManchester University NHS Foundation Trust, Manchester, UK,Manchester Univ NHS Fdn Trust, England (författare)
Brunnegård, KarinUmeå universitet,Logopedi,Umea Univ, Sweden(Swepub:umu)kabr0001 (författare)
Cairns, GillianRoyal Hospital for Sick Children, Edinburgh, UK,Royal Hosp Sick Children, Scotland (författare)
Calladine, SamanthaNorthern and Yorkshire Regional Cleft Lip and Palate Service, Leeds, UK,Northern & Yorkshire Reg Cleft Lip & Palate Serv, England (författare)
Campbell, LinsayCleft Care Scotland, Glasgow, UK (författare)
Clayton-Smith, JillUniversity of Manchester, Manchester, UK,Univ Manchester, England (författare)
Cooper, RachaelUniversity of Liverpool, Liverpool, UK,Univ Liverpool, England (författare)
Conroy, ElizabethUniversity of Liverpool, Liverpool, UK,Univ Liverpool, England (författare)
El-Angbawi, AhmedUniversity of Manchester, Manchester, UK,Univ Manchester, England (författare)
Kildegaard Emborg, BeritCleft Palate Center, Aarhus, Denmark,Cleft Palate Ctr, Denmark (författare)
Enfält Wikman, JosefinNorrlands University Hospital, Umeå, Sweden,Norrlands Univ Hosp, Sweden (författare)
Fitzpatrick, BethBirmingham Children’s Hospital, Birmingham, UK,Birmingham Childrens Hosp, England (författare)
Fukushiro, Ana PaulaUniversity of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil (författare)
Guedes de Azevedo Bento Gonçalves, CristinaUniversity of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil (författare)
Havstam, ChristinaSahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden (författare)
Hvistendahl, Anne KatherineStatped, Oslo, Norway (författare)
Jorgensen, Line DahlUniversity of Copenhagen, Copenhagen, Denmark; Copenhagen Cleft Palate Center, Copenhagen, Denmark,Univ Copenhagen, Denmark; Copenhagen Cleft Palate Ctr, Denmark (författare)
Klinto, KristinaSkåne University Hospital, Malmö, Sweden,Skane Univ Hosp, Sweden (författare)
Berntsen Kvinnsland, MaritStatped, Oslo, Norway (författare)
Larham, CatrionaLeeds General Infirmary, UK,Leeds Gen Infirm, England (författare)
Lemvik, JorunnStatped, Oslo, Norway (författare)
Leturgie, LouiseCleft Palate Center, Aarhus, Denmark,Cleft Palate Ctr, Denmark (författare)
Liljerehn, EvaUppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden (författare)
Lodge, NatalieRoyal Hospital for Sick Children, Liverpool, UK,Royal Hosp Sick Children, Scotland (författare)
Lohmander, AnetteKarolinska Institutet (författare)
McMahon, SiobhanAlder Hey Children’s NHS Foundation Trust, UK,Alder Hey Childrens NHS Fdn Trust, England (författare)
Mehendale, FelicityUniversity of Edinburgh, Edinburgh, UK,Univ Edinburgh, Scotland (författare)
Miguel, Haline CoracineUniversity of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil (författare)
Moe, MarianneStatped Sørøst, Oslo, Norway (författare)
Nielsen, Joan BoghCleft Palate Center, Aarhus, Denmark,Cleft Palate Ctr, Denmark (författare)
Nyberg, JillKarolinska Institutet, Solna, Sweden,Karolinska Inst, Sweden (författare)
Pedersen, Nina-HelenStatped Vest, Bergen, Norway (författare)
Phippen, GinetteSalisbury District Hospital, Salisbury, UK,Salisbury Dist Hosp, England (författare)
Alvarez Piazentin-Penna, Silvia HelenaUniversity of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil (författare)
Patrick, KathrynManchester University NHS Foundation Trust, Manchester, UK,Manchester Univ NHS Fdn Trust, England (författare)
Pliskin, LindsayUniversity of Liverpool, Liverpool, UK,Univ Liverpool, England (författare)
Rigby, LucyRoyal Victoria Infirmary, Newcastle upon Tyne, UK,Royal Victoria Infirm, England (författare)
Semb, GunvorUniversity of Manchester, Manchester, UK,Univ Manchester, England (författare)
Southby, LucyOxford University Hospitals NHS Foundation Trust, Oxford, UK,Oxford Univ Hosp NHS Fdn Trust, England (författare)
Sporre, MariaSkåne University Hospital, Malmö, Sweden,Skane Univ Hosp, Sweden (författare)
Björkman Taleman, Ann-SofieLinköping University Hospital, Linköping, Sweden,Region Östergötland(Swepub:liu)n/a (författare)
Tangstad, JoridStatped Vest, Bergen, Norway (författare)
Trindade, Inge Elly KiemleUniversity of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil (författare)
Underwood, ImogenBirmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK,Birmingham Womens & Childrens NHS Fdn Trust, England (författare)
van Eeden, StephanieRoyal Victoria Infirmary, Newcastle upon Tyne, UK,Royal Victoria Infirm, England (författare)
Westberg, Liisi RaudKarolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden (författare)
Williamson, Paula RuthUniversity of Liverpool, Liverpool, UK,Univ Liverpool, England (författare)
Paciello Yamashita, RenataUniversity of São Paulo, Bauru, Brazil,Univ Sao Paulo, Brazil (författare)
Munro, KevinUniversity of Manchester, Liverpool, UK,Univ Manchester, England (författare)
Walsh, TanyaUniversity of Manchester, Manchester, UK,Univ Manchester, England (författare)
Shaw, WilliamUniversity of Manchester, Manchester, UK,Univ Manchester, England (författare)
University of Liverpool, Liverpool, UKUniv Liverpool, England (creator_code:org_t)

Sammanhörande titlar

Ingår i:The New England journal of medicine: Massachusetts Medical Society389:9, s. 795-8071533-44060028-4793

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Av författaren/redakt...: Gamble, Carrol; Persson, Christi ...; Willadsen, Elisa ...; Albery, Liz; Soegaard Anderse ...; Zattoni Antoneli ...; visa fler...; Appelqvist, Mali ...; Aukner, Ragnhild; Bodling, Pia; Bowden, Melanie; Brunnegård, Kari ...; Cairns, Gillian; Calladine, Saman ...; Campbell, Linsay; Clayton-Smith, J ...; Cooper, Rachael; Conroy, Elizabet ...; El-Angbawi, Ahme ...; Kildegaard Embor ...; Enfält Wikman, J ...; Fitzpatrick, Bet ...; Fukushiro, Ana P ...; Guedes de Azeved ...; Havstam, Christi ...; Hvistendahl, Ann ...; Jorgensen, Line ...; Klinto, Kristina; Berntsen Kvinnsl ...; Larham, Catriona; Lemvik, Jorunn; Leturgie, Louise; Liljerehn, Eva; Lodge, Natalie; Lohmander, Anett ...; McMahon, Siobhan; Mehendale, Felic ...; Miguel, Haline C ...; Moe, Marianne; Nielsen, Joan Bo ...; Nyberg, Jill; Pedersen, Nina-H ...; Phippen, Ginette; Alvarez Piazenti ...; Patrick, Kathryn; Pliskin, Lindsay; Rigby, Lucy; Semb, Gunvor; Southby, Lucy; Sporre, Maria; Björkman Taleman ...; Tangstad, Jorid; Trindade, Inge E ...; Underwood, Imoge ...; van Eeden, Steph ...; Westberg, Liisi ...; Williamson, Paul ...; Paciello Yamashi ...; Munro, Kevin; Walsh, Tanya; Shaw, William; visa färre...

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