Search: WFRF:(Coll M.)
> (2020-2023) >
Arabidopsis metacas...
Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence
-
Ruiz-Solani, N. (author)
-
Salguero-Linares, J. (author)
-
Armengot, L. (author)
-
show more...
-
Santos, J. (author)
-
Pallares, I. (author)
-
van Midden, K. P. (author)
-
Phukkan, U. J. (author)
-
Koyuncu, S. (author)
-
Borras-Bisa, J. (author)
-
Li, L. (author)
-
Popa, C. (author)
-
- Eisele, Frederik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
- Eisele-Bürger, Anna Maria (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
- Hill, Sandra Malmgren, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
Gutierrez-Beltran, E. (author)
-
Nystrom, T. (author)
-
Valls, M. (author)
-
Llamas, E. (author)
-
Vilchez, D. (author)
-
Klemencic, M. (author)
-
Ventura, S. (author)
-
Coll, N. S. (author)
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Plant Cell. - 1040-4651. ; 35:9, s. 3325-3344
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The Arabidopsis metacaspase MC1 is recruited to stress granules upon proteotoxic stress, participates in clearance of pathological protein aggregates, and delays senescence. Stress granules (SGs) are highly conserved cytoplasmic condensates that assemble in response to stress and contribute to maintaining protein homeostasis. These membraneless organelles are dynamic, disassembling once the stress is no longer present. Persistence of SGs due to mutations or chronic stress has been often related to age-dependent protein-misfolding diseases in animals. Here, we find that the metacaspase MC1 is dynamically recruited into SGs upon proteotoxic stress in Arabidopsis (Arabidopsis thaliana). Two predicted disordered regions, the prodomain and the 360 loop, mediate MC1 recruitment to and release from SGs. Importantly, we show that MC1 has the capacity to clear toxic protein aggregates in vivo and in vitro, acting as a disaggregase. Finally, we demonstrate that overexpressing MC1 delays senescence and this phenotype is dependent on the presence of the 360 loop and an intact catalytic domain. Together, our data indicate that MC1 regulates senescence through its recruitment into SGs and this function could potentially be linked to its remarkable protein aggregate-clearing activity.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- liquid phase-separation
- programmed cell-death
- processing bodies
- crystal-structure
- rna
- transthyretin
- paracaspases
- degradation
- mechanism
- disease
- Biochemistry & Molecular Biology
- Plant Sciences
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Plant Cell
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Ruiz-Solani, N.
-
Salguero-Linares ...
-
Armengot, L.
-
Santos, J.
-
Pallares, I.
-
van Midden, K. P ...
-
show more...
-
Phukkan, U. J.
-
Koyuncu, S.
-
Borras-Bisa, J.
-
Li, L.
-
Popa, C.
-
Eisele, Frederik
-
Eisele-Bürger, A ...
-
Hill, Sandra Mal ...
-
Gutierrez-Beltra ...
-
Nystrom, T.
-
Valls, M.
-
Llamas, E.
-
Vilchez, D.
-
Klemencic, M.
-
Ventura, S.
-
Coll, N. S.
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
- Articles in the publication
-
Plant Cell
- By the university
-
University of Gothenburg