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High use of pain, d...
High use of pain, depression, and anxiety drugs in hemophilia: more than 3000 people with hemophilia in an 11-year Nordic registry study
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- Steen Carlsson, Katarina (författare)
- Lund University,Lunds universitet,Hälsoekonomi,Forskargrupper vid Lunds universitet,Health Economics,Lund University Research Groups,IHE – The Swedish Institute for Health Economics
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- Winding, Bent (författare)
- Swedish Orphan Biovitrum AB, Sweden
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- Astermark, Jan (författare)
- Skane Univ Hosp, Sweden,Skåne University Hospital
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- Baghaei, Fariba, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Brodin, Elisabeth (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden,Sahlgrenska Academy,Sahlgrenska University Hospital
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- Funding, Eva (författare)
- Rigshosp, Denmark; Univ Copenhagen, Denmark,University of Copenhagen,Copenhagen University Hospital
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- Holmström, Margareta (författare)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken,Karolinska Univ Hosp, Sweden,Karolinska University Hospital
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- Österholm, Klaus (författare)
- Helsinki Univ Hosp, Finland,Helsinki University Central Hospital
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- Bergenstråle, Sofia (författare)
- Swedish Orphan Biovitrum AB, Sweden
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- Lethagen, Stefan (författare)
- Swedish Orphan Biovitrum AB, Sweden
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: Research and Practice in Thrombosis and Haemostasis. - : Elsevier BV. - 2475-0379. ; 7:2
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Pain is a common feature of hemophilia, but prevalence of depression and anxiety is less studied. Registry data on prescription drugs can provide an objective measure of the magnitude of these complications. Objectives: To identify treatment patterns of prescribed pain, antidepressant, and antianxiety medications compared with those of matched controls in 4 Nordic countries. Methods: The MIND study (NCT03276130) analyzed longitudinal individual-level national data during 2007-2017. People with hemophilia (PwH) were identified from National Health Data Registers by diagnosis or factor replacement treatment and compared with population controls. Three subgroups were defined by the use of factor concentrates and sex (moderate-to-high factor consumption (factor VIII [FVIII] use of ≥40 IU/kg/week or FIX use of ≥10 IU/kg/week), low factor consumption, and women including carriers). Results: Data of 3246 PwH, representing 30,184 person-years, were analyzed. PwH (including children and adults) used more pain, depression, and anxiety medications compared with controls. This was most accentuated in the moderate-to-high factor consumption group and notably also observed in men with low factor consumption and women including carriers, usually representing a milder phenotype. A higher opioid use was observed across all age groups: 4- to 6-fold higher in the moderate-to-high factor consumption group and 2- to 4-fold higher in the low factor consumption group. Conclusion: The consistent higher use of pain, depression, and anxiety medications among PwH compared with population controls, regardless of age, sex, or factor consumption, in broad national data suggests a need for improved bleed protection and hemophilia care for all severities including mild hemophilia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- analgesics
- opioid
- anxiety
- case-control studies
- depression
- drug utilization
- female
- hemophilia A
- hemophilia B
- pain
- prescription drugs
- anxiety; case-control studies; depression; drug utilization; female; hemophilia A; hemophilia B; analgesics; opioid; pain; prescription drugs
- analgesics, opioid
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- ref (ämneskategori)
- art (ämneskategori)
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Steen Carlsson, ...
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Winding, Bent
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Astermark, Jan
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Baghaei, Fariba, ...
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Brodin, Elisabet ...
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Funding, Eva
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Holmström, Marga ...
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Österholm, Klaus
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Bergenstråle, So ...
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Lethagen, Stefan
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- Av lärosätet
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Göteborgs universitet
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Linköpings universitet
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Lunds universitet