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Airway and systemic...
Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles - A randomized controlled double-blind crossover study among mild asthmatic subjects
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- Laursen, K. R. (författare)
- Aarhus University
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- Christensen, N. V. (författare)
- Aarhus University
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- Mulder, F. A. A. (författare)
- Aarhus University
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visa fler...
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- Schullehner, J. (författare)
- Geological Survey of Denmark and Greenland, Copenhagen, Denmark,Aarhus University
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- Hoffmann, H. J. (författare)
- Aarhus University Hospital
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- Jensen, A. (författare)
- University of Copenhagen
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- Moller, P. (författare)
- University of Copenhagen
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- Loft, S. (författare)
- University of Copenhagen
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- Olin, Anna-Carin, 1960 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Rasmussen, B. B. (författare)
- Aarhus University
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- Rosati, B. (författare)
- Aarhus University,University of Vienna
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- Strandberg, Bo (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH
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- Glasius, M. (författare)
- Aarhus University
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- Bilde, M. (författare)
- Aarhus University
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- Sigsgaard, T. (författare)
- Aarhus University
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(creator_code:org_t)
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- 2023
- 2023
- Engelska.
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Ingår i: Particle and Fibre Toxicology. - 1743-8977. ; 20:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BackgroundThere is insufficient knowledge about the systemic health effects of exposure to fine (PM2.5) and ultrafine particles emitted from typical indoor sources, including cooking and candlelight burning. We examined whether short-term exposure to emissions from cooking and burning candles cause inflammatory changes in young individuals with mild asthma. Thirty-six non-smoking asthmatics participated in a randomized controlled double-blind crossover study attending three exposure sessions (mean PM2.5 & mu;g/m(;)(3) polycyclic aromatic hydrocarbons ng/m(3)): (a) air mixed with emissions from cooking (96.1; 1.1), (b) air mixed with emissions from candles (89.8; 10), and (c) clean filtered air (5.8; 1.0). Emissions were generated in an adjacent chamber and let into a full-scale exposure chamber where participants were exposed for five hours. Several biomarkers were assessed in relation to airway and systemic inflammatory changes; the primary outcomes of interest were surfactant Protein-A (SP-A) and albumin in droplets in exhaled air - novel biomarkers for changes in the surfactant composition of small airways. Secondary outcomes included cytokines in nasal lavage, cytokines, C-reactive protein (CRP), epithelial progenitor cells (EPCs), genotoxicity, gene expression related to DNA-repair, oxidative stress, and inflammation, as well as metabolites in blood. Samples were collected before exposure start, right after exposure and the next morning.ResultsSP-A in droplets in exhaled air showed stable concentrations following candle exposure, while concentrations decreased following cooking and clean air exposure. Albumin in droplets in exhaled air increased following exposure to cooking and candles compared to clean air exposure, although not significant. Oxidatively damaged DNA and concentrations of some lipids and lipoproteins in the blood increased significantly following exposure to cooking. We found no or weak associations between cooking and candle exposure and systemic inflammation biomarkers including cytokines, CRP, and EPCs.ConclusionsCooking and candle emissions induced effects on some of the examined health-related biomarkers, while no effect was observed in others; Oxidatively damaged DNA and concentrations of lipids and lipoproteins were increased in blood after exposure to cooking, while both cooking and candle emissions slightly affected the small airways including the primary outcomes SP-A and albumin. We found only weak associations between the exposures and systemic inflammatory biomarkers. Together, the results show the existence of mild inflammation following cooking and candle exposure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Indoor air
- Ultrafine particles
- Human exposure
- Cooking
- Candles
- Inflammation
- SP-A
- Metabolomics
- Biomarkers
- Oxidatively damaged DNA
- surfactant protein-a
- oxidatively damaged DNA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Laursen, K. R.
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Christensen, N. ...
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Mulder, F. A. A.
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Schullehner, J.
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Hoffmann, H. J.
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Jensen, A.
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visa fler...
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Moller, P.
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Loft, S.
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Olin, Anna-Carin ...
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Rasmussen, B. B.
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Rosati, B.
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Strandberg, Bo
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Glasius, M.
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Bilde, M.
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Sigsgaard, T.
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