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Factors Associated ...
Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.
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Marriott, Ross J (författare)
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Murray, Kevin (författare)
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Adams, Robert J (författare)
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visa fler...
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Antonio, Leen (författare)
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Ballantyne, Christie M (författare)
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Bauer, Douglas C (författare)
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Bhasin, Shalender (författare)
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Biggs, Mary L (författare)
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Cawthon, Peggy M (författare)
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Couper, David J (författare)
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Dobs, Adrian S (författare)
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Flicker, Leon (författare)
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Handelsman, David J (författare)
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Hankey, Graeme J (författare)
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Hannemann, Anke (författare)
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Haring, Robin (författare)
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Hsu, Benjumin (författare)
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Karlsson, Magnus (författare)
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Martin, Sean A (författare)
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Matsumoto, Alvin M (författare)
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- Mellström, Dan, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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O'Neill, Terence W (författare)
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Orwoll, Eric S (författare)
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Quartagno, Matteo (författare)
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Shores, Molly M (författare)
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Steveling, Antje (författare)
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- Tivesten, Åsa, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Travison, Thomas G (författare)
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Vanderschueren, Dirk (författare)
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Wittert, Gary A (författare)
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Wu, Frederick C W (författare)
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Yeap, Bu B (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Annals of internal medicine. - 1539-3704. ; 176:9, s. 1221-1234
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements.To clarify factors associated with variations in sex hormone concentrations.Systematic literature searches (to July 2019).Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.Individual participant data (IPD) (9 studies; n= 21074) and aggregate data (2 studies; n= 4075). Sociodemographic, lifestyle, and health factors and concentrations of total testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, and estradiol were extracted.Two-stage random-effects IPD meta-analyses found a nonlinear association of testosterone with age, with negligible change among men aged 17 to 70 years (change per SD increase about the midpoint, -0.27 nmol/L [-7.8 ng/dL] [CI, -0.71 to 0.18 nmol/L {-20.5 to 5.2 ng/dL}]) and decreasing testosterone levels with age for men older than 70 years (-1.55 nmol/L [-44.7 ng/dL] [CI, -2.05 to -1.06 nmol/L {-59.1 to -30.6 ng/dL}]). Testosterone was inversely associated with body mass index (BMI) (change per SD increase, -2.42 nmol/L [-69.7 ng/dL] [CI, -2.70 to -2.13 nmol/L {-77.8 to -61.4 ng/dL}]). Testosterone concentrations were lower for men who were married (mean difference, -0.57 nmol/L [-16.4 ng/dL] [CI, -0.89 to -0.26 nmol/L {-25.6 to -7.5 ng/dL}]); undertook at most 75 minutes of vigorous physical activity per week (-0.51 nmol/L [-14.7 ng/dL] [CI, -0.90 to -0.13 nmol/L {-25.9 to -3.7 ng/dL}]); were former smokers (-0.34 nmol/L [-9.8 ng/dL] [CI, -0.55 to -0.12 nmol/L {-15.9 to -3.5 ng/dL}]); or had hypertension (-0.53 nmol/L [-15.3 ng/dL] [CI, -0.82 to -0.24 nmol/L {-23.6 to -6.9 ng/dL}]), cardiovascular disease (-0.35 nmol/L [-10.1 ng/dL] [CI, -0.55 to -0.15 nmol/L {-15.9 to -4.3 ng/dL}]), cancer (-1.39 nmol/L [-40.1 ng/dL] [CI, -1.79 to -0.99 nmol/L {-51.6 to -28.5 ng/dL}]), or diabetes (-1.43 nmol/L [-41.2 ng/dL] [CI, -1.65 to -1.22 nmol/L {-47.6 to -35.2 ng/dL}]). Sex hormone-binding globulin was directly associated with age and inversely associated with BMI. Luteinizing hormone was directly associated with age in men older than 70 years.Cross-sectional analysis, heterogeneity between studies and in timing of blood sampling, and imputation for missing data.Multiple factors are associated with variation in male testosterone, SHBG, and LH concentrations. Reduced testosterone and increased LH concentrations may indicate impaired testicular function after age 70 years. Interpretation of individual testosterone measurements should account particularly for age older than 70 years, obesity, diabetes, and cancer.Medical Research Future Fund, Government of Western Australia, and Lawley Pharmaceuticals. (PROSPERO: CRD42019139668).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Humans
- Male
- Adolescent
- Young Adult
- Adult
- Middle Aged
- Aged
- Sex Hormone-Binding Globulin
- Cross-Sectional Studies
- Prospective Studies
- Gonadal Steroid Hormones
- Testosterone
- Luteinizing Hormone
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Marriott, Ross J
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Murray, Kevin
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Adams, Robert J
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Antonio, Leen
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Ballantyne, Chri ...
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Bauer, Douglas C
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visa fler...
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Bhasin, Shalende ...
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Biggs, Mary L
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Cawthon, Peggy M
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Couper, David J
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Dobs, Adrian S
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Flicker, Leon
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Handelsman, Davi ...
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Hankey, Graeme J
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Hannemann, Anke
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Haring, Robin
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Hsu, Benjumin
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Karlsson, Magnus
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Martin, Sean A
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Matsumoto, Alvin ...
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Mellström, Dan, ...
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Ohlsson, Claes, ...
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O'Neill, Terence ...
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Orwoll, Eric S
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Quartagno, Matte ...
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Shores, Molly M
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Steveling, Antje
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Tivesten, Åsa, 1 ...
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Travison, Thomas ...
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Vanderschueren, ...
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Wittert, Gary A
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Wu, Frederick C ...
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Yeap, Bu B
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Göteborgs universitet