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An atlas of genetic...
An atlas of genetic determinants of forearm fracture.
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- Nethander, Maria, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Movérare-Skrtic, Sofia (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Kämpe, Anders (författare)
- Karolinska Institute,Karolinska Institutet,University of Helsinki
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- Coward, Eivind (författare)
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
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- Reimann, Ene (författare)
- Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Grahnemo, Louise (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Borbély, Éva (författare)
- Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; National Laboratory for Drug Research and Development, Budapest, Hungary
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- Helyes, Zsuzsanna (författare)
- Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; National Laboratory for Drug Research and Development, Budapest, Hungary; Eotvos Lorand Research Network, Chronic Pain Research Group, University of Pécs, Pécs, Hungary
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- Funck-Brentano, Thomas (författare)
- BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France
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- Cohen-Solal, Martine (författare)
- BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France
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- Tuukkanen, Juha (författare)
- Department of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu, Oulu, Finland
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- Koskela, Antti (författare)
- Department of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu, Oulu, Finland
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- Wu, Jianyao (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Li, Lei, 1985 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Lu, Tianyuan (författare)
- Lady Davis Institute for Medical Research, Jewish General Hospital, QC, Montreal, Canada
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- Gabrielsen, Maiken E (författare)
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
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- Mägi, Reedik (författare)
- Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Hoff, Mari (författare)
- Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway; Department of Rheumatology, St Olavs Hospital, Trondheim, Norway
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- Lerner, Ulf H (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Henning, Petra, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Ullum, Henrik (författare)
- Statens Serum Institut, Copenhagen, Denmark,Danish Serum Institute, Copenhagen
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- Erikstrup, Christian (författare)
- Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
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- Brunak, Søren (författare)
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Langhammer, Arnulf (författare)
- Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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- Tuomi, Tiinamaija (författare)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital
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- Oddsson, Asmundur (författare)
- deCODE genetics, Reykjavik, Iceland
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- Stefansson, Kari (författare)
- deCODE genetics, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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- Pettersson-Kymmer, Ulrika (författare)
- Umeå University,Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Ostrowski, Sisse Rye (författare)
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Immunology, Copenhagen Hospital Biobank Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
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- Pedersen, Ole Birger Vesterager (författare)
- Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Immunology, Zealand University Hospital, Koege, Denmark
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- Styrkarsdottir, Unnur (författare)
- deCODE genetics, Reykjavik, Iceland
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- Mäkitie, Outi (författare)
- Karolinska Institute,Karolinska Institutet,Folkhälsan Research Center,University of Helsinki
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- Hveem, Kristian (författare)
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, and Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
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- Richards, J Brent (författare)
- Lady Davis Institute for Medical Research, Jewish General Hospital, QC, Montreal, Canada; Department of Human Genetics, McGill University, QC, Montreal, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Nature genetics. - : Springer Nature. - 1546-1718 .- 1061-4036. ; 55:11, s. 1820-1830
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,026 forearm fracture cases. We identified 43 loci, including 26 new fracture loci. Although most fracture loci associated with bone mineral density, we also identified loci that primarily regulate bone quality parameters. Functional studies of one such locus, at TAC4, revealed that Tac4-/- mice have reduced mechanical bone strength. The strongest forearm fracture signal, at WNT16, displayed remarkable bone-site-specificity with no association with hip fractures. Tall stature and low body mass index were identified as new causal risk factors for fractures. The insights from this atlas may improve fracture prediction and enable therapeutic development to prevent fractures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Animals
- Mice
- Forearm
- Genome-Wide Association Study
- Fractures
- Bone
- genetics
- Bone Density
- genetics
- Risk Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nethander, Maria ...
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Movérare-Skrtic, ...
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Kämpe, Anders
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Coward, Eivind
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Reimann, Ene
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Grahnemo, Louise
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visa fler...
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Borbély, Éva
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Helyes, Zsuzsann ...
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Funck-Brentano, ...
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Cohen-Solal, Mar ...
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Tuukkanen, Juha
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Koskela, Antti
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Wu, Jianyao
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Li, Lei, 1985
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Lu, Tianyuan
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Gabrielsen, Maik ...
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Mägi, Reedik
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Hoff, Mari
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Lerner, Ulf H
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Henning, Petra, ...
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Ullum, Henrik
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Erikstrup, Chris ...
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Brunak, Søren
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Langhammer, Arnu ...
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Tuomi, Tiinamaij ...
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Oddsson, Asmundu ...
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Stefansson, Kari
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Pettersson-Kymme ...
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Ostrowski, Sisse ...
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Pedersen, Ole Bi ...
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Styrkarsdottir, ...
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Mäkitie, Outi
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Hveem, Kristian
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Richards, J Bren ...
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Ohlsson, Claes, ...
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Nature genetics
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet