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Impact of autofluor...
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Bergenfelz, AndersLund University,Lunds universitet,Endokrin- och sarkomkirurgi,Forskargrupper vid Lunds universitet,Endocrine and Sarcoma Surgery,Lund University Research Groups
(author)
Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/330481
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https://gup.ub.gu.se/publication/330481URI
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https://doi.org/10.1093/bjs/znad278DOI
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https://lup.lub.lu.se/record/5aae0cbc-6079-4181-b4d3-c80e8ca9024eURI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BACKGROUND: Techniques for autofluorescence have been introduced to visualize the parathyroid glands during surgery and to reduce hypoparathyroidism after thyroidectomy. METHODS: This parallel multicentre RCT investigated the use of Fluobeam® LX to visualize the parathyroid glands by autofluorescence during total thyroidectomy compared with no use. There was no restriction on the indication for surgery. Patients were randomized 1 : 1 and were blinded to the group allocation. The hypothesis was that autofluorescence enables identification and protection of the parathyroid glands during thyroidectomy. The primary endpoint was the rate of low parathyroid hormone (PTH) levels the day after surgery. RESULTS: Some 535 patients were randomized, and 486 patients received an intervention according to the study protocol, 246 in the Fluobeam® LX group and 240 in the control group. Some 64 patients (26.0 per cent) in the Fluobeam® LX group and 77 (32.1 per cent) in the control group had low levels of PTH after thyroidectomy (P = 0.141; relative risk (RR) 0.81, 95 per cent c.i. 0.61 to 1.07). Subanalysis of 174 patients undergoing central lymph node clearance showed that 15 of 82 (18 per cent) in the Fluobeam® LX group and 31 of 92 (33 per cent) in the control group had low levels of PTH on postoperative day 1 (P = 0.021; RR 0.54, 0.31 to 0.93). More parathyroid glands were identified during operation in patients who had surgery with Fluobeam® LX, and fewer parathyroid glands in the surgical specimen on definitive histopathology. No specific harm related to the use of Fluobeam® LX was reported. CONCLUSION: The use of autofluorescence during thyroidectomy did not reduce the rate of low PTH levels on postoperative day 1 in the whole group of patients. It did, however, reduce the rate in a subgroup of patients.
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Barczynski, MarcinJagiellonian University
(author)
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Heie, AnetteHaukeland University Hospital
(author)
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Muth, Andreas,1974Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:gu)xmutan
(author)
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Passler, Christian
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Schneider, Max
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Wierzbicka, PaulinaJagiellonian University
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Konturek, AlexanderJagiellonian University
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Brauckhoff, KatrinHaukeland University Hospital,University of Bergen
(author)
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Elf, Anna-KarinGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:gu)xelfay
(author)
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Dahlberg, Jakob,1969Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:gu)xdajak
(author)
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Hermann, MichaelKlinik Landstraße
(author)
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Endokrin- och sarkomkirurgiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:The British journal of surgery110:12, s. 1824-18331365-21680007-1323
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