How chromosomal inversions reorient the evolutionary process

Inversions are structural mutations that reverse the sequence of a chromosome seg-ment and reduce the effective rate of recombination in the heterozygous state. They play a major role in adaptation, as well as in other evolutionary processes such as spe-ciation. Although inversions have been studied since the 1920s, they remain difficult to investigate because the reduced recombination conferred by them strengthens the effects of drift and hitchhiking, which in turn can obscure signatures of selection. Nonetheless, numerous inversions have been found to be under selection. Given re-cent advances in population genetic theory and empirical study, here we review how different mechanisms of selection affect the evolution of inversions. A key difference between inversions and other mutations, such as single nucleotide variants, is that the fitness of an inversion may be affected by a larger number of frequently interacting processes. This considerably complicates the analysis of the causes underlying the evolution of inversions. We discuss the extent to which these mechanisms can be disentangled, and by which approach.

Barton, Nicholas (author)
Butlin, Roger,1955Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Linnécentrum för marin evolutionsbiologi (CEMEB),Department of marine sciences,Linnaeus Centre for Marine Evolutionary Biology (CEMEB)(Swepub:gu)xbutro (author)
Charlesworth, Brian (author)
Faria, Rui (author)
Fragata, Inês (author)
Gilbert, Kimberly J. (author)
Jay, Paul (author)
Kapun, Martin (author)
Lotterhos, Katie E. (author)
Mérot, Claire (author)
Durmaz Mitchell, Esra (author)
Pascual, Marta (author)
Peichel, Catherine L. (author)
Rafajlović, Marina,1983Gothenburg University,Göteborgs universitet,Linnécentrum för marin evolutionsbiologi (CEMEB),Institutionen för marina vetenskaper,Linnaeus Centre for Marine Evolutionary Biology (CEMEB),Department of marine sciences(Swepub:gu)xrafma (author)
Westram, Anja Marie,1983 (author)
Schaeffer, Stephen W. (author)
Johannesson, Kerstin,1955Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper, Tjärnö marinlaboratoriet,Linnécentrum för marin evolutionsbiologi (CEMEB),Department of marine sciences, Tjärnö Marine Laboratory,Linnaeus Centre for Marine Evolutionary Biology (CEMEB)(Swepub:gu)xjoker (author)
Flatt, Thomas (author)
Göteborgs universitetInstitutionen för marina vetenskaper (creator_code:org_t)

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Evolutionary Bio ...

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