Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: A report from the International RRD Consortium.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Hawkins Cynthia) > Combined immunother...

Details
MARC

Das, Anirban (author)

Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: A report from the International RRD Consortium.

Article/chapterEnglish2024

Publisher, publication year, extent ...

2024

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/330985
https://gup.ub.gu.se/publication/330985URI
https://doi.org/10.1158/2159-8290.CD-23-0559DOI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Immune-checkpoint inhibition (ICI) is effective for replication-repair deficient, high-grade gliomas (RRD-HGG). Clinical/biologic impact of immune-directed approaches after failing ICI-monotherapy are unknown. We performed an international study on 75 patients treated with anti-PD1; 20 are progression-free (median follow-up: 3.7-years). After 2nd-progression/recurrence (n=55), continuing ICI-based salvage prolonged survival to 11.6-months (n=38; p<0.001), particularly for those with extreme mutation burden (p=0.03). Delayed, sustained responses were observed, associated with changes in mutational spectra and immune-microenvironment. Response to re-irradiation was explained by an absence of deleterious post-radiation indel signatures (ID8). Increased CTLA4-expression over time, and subsequent CTLA4-inhibition resulted in response/stable disease in 75%. RAS-MAPK-pathway inhibition led to reinvigoration of peripheral immune and radiological responses. Local (flare) and systemic immune adverse events were frequent (biallelic mismatch-repair deficiency > Lynch syndrome). We provide mechanistic rationale for the sustained benefit in RRD-HGG from immune-directed/ synergistic salvage therapies. Future approaches need to be tailored to patient and tumor biology.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Fernandez, Nicholas R (author)
Levine, Adrian (author)
Bianchi, Vanessa (author)
Stengs, Lucie K (author)
Chung, Jiil (author)
Negm, Logine (author)
Dimayacyac, Jose Rafael (author)
Chang, Yuan (author)
Nobre, Liana (author)
Ercan, Ayse B (author)
Sanchez-Ramirez, Santiago (author)
Sudhaman, Sumedha (author)
Edwards, Melissa (author)
Larouche, Valerie (author)
Samuel, David (author)
Van Damme, An (author)
Gass, David (author)
Ziegler, David S (author)
Bielack, Stefan S (author)
Koschmann, Carl (author)
Zelcer, Shayna (author)
Yalon-Oren, Michal (author)
Campino, Gadi Abede (author)
Sarosiek, Tomasz (author)
Nichols, Kim E (author)
Loret De Mola, Rebecca (author)
Bielamowicz, Kevin (author)
Sabel, Magnus,1966Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xsabma (author)
Frojd, Charlotta A (author)
Wood, Matthew D (author)
Glover, Jason M (author)
Lee, Yi-Yen (author)
Vanan, Magimairajan (author)
Adamski, Jenny K (author)
Perreault, Sebastien (author)
Chamdine, Omar (author)
Hjort, Magnus Aasved (author)
Zapotocky, Michal (author)
Carceller, Fernando (author)
Wright, Erin (author)
Fedorakova, Ivana (author)
Lossos, Alexander (author)
Tanaka, Ryuma (author)
Osborn, Michael (author)
Blumenthal, Deborah T (author)
Aronson, Melyssa (author)
Bartels, Ute (author)
Huang, Annie (author)
Ramaswamy, Vijay (author)
Malkin, David (author)
Shlien, Adam (author)
Villani, Anita (author)
Dirks, Peter B (author)
Pugh, Trevor J (author)
Getz, Gad (author)
Maruvka, Yosef E (author)
Tsang, Derek S (author)
Ertl-Wagner, Birgit (author)
Hawkins, Cynthia (author)
Bouffet, Eric (author)
Morgenstern, Daniel A (author)
Tabori, Uri (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik (creator_code:org_t)

Related titles

In:Cancer discovery14:2, s. 258-2732159-8290

Internet link

Find in a library

Cancer discovery (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Das, Anirban; Fernandez, Nicho ...; Levine, Adrian; Bianchi, Vanessa; Stengs, Lucie K; Chung, Jiil; show more...; Negm, Logine; Dimayacyac, Jose ...; Chang, Yuan; Nobre, Liana; Ercan, Ayse B; Sanchez-Ramirez, ...; Sudhaman, Sumedh ...; Edwards, Melissa; Larouche, Valeri ...; Samuel, David; Van Damme, An; Gass, David; Ziegler, David S; Bielack, Stefan ...; Koschmann, Carl; Zelcer, Shayna; Yalon-Oren, Mich ...; Campino, Gadi Ab ...; Sarosiek, Tomasz; Nichols, Kim E; Loret De Mola, R ...; Bielamowicz, Kev ...; Sabel, Magnus, 1 ...; Frojd, Charlotta ...; Wood, Matthew D; Glover, Jason M; Lee, Yi-Yen; Vanan, Magimaira ...; Adamski, Jenny K; Perreault, Sebas ...; Chamdine, Omar; Hjort, Magnus Aa ...; Zapotocky, Micha ...; Carceller, Ferna ...; Wright, Erin; Fedorakova, Ivan ...; Lossos, Alexande ...; Tanaka, Ryuma; Osborn, Michael; Blumenthal, Debo ...; Aronson, Melyssa; Bartels, Ute; Huang, Annie; Ramaswamy, Vijay; Malkin, David; Shlien, Adam; Villani, Anita; Dirks, Peter B; Pugh, Trevor J; Getz, Gad; Maruvka, Yosef E; Tsang, Derek S; Ertl-Wagner, Bir ...; Hawkins, Cynthia; Bouffet, Eric; Morgenstern, Dan ...; Tabori, Uri; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Cancer discovery

By the university: University of Gothenburg

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se