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Changes in adipose ...
Changes in adipose tissue distribution and relation to cardiometabolic risk factors after Roux-en-Y in adolescents
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- Beamish, A. J. (författare)
- Sahlgrens Univ Hosp, Sweden; Swansea Univ, Wales; Royal Coll Surgeons England, England; Morriston Hosp, Wales
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- Dengel, O. H. (författare)
- Univ Minnesota, MN USA
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- Palzer, E. F. (författare)
- Univ Minnesota, MN USA
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- Gronowitz, Eva, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden
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- Kelly, A. S. (författare)
- Univ Minnesota, MN USA
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- Dengel, D. R. (författare)
- Univ Minnesota, MN USA
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Rudser, K. D. (författare)
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- Brissman, M. (författare)
- Karolinska Institutet
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- Olbers, Torsten (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken ViN
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- Dahlgren, Jovanna, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden
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- Flodmark, C. E. (författare)
- Skane Univ Hosp, Sweden
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- Marcus, C. (författare)
- Karolinska Institutet
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- Ryder, J. R. (författare)
- Ann & Robert H Lurie Childrens Hosp Chicago, IL USA; Northwestern Feinberg Sch Med, IL USA
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2023
- 2023
- Engelska.
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Ingår i: Surgery for Obesity and Related Diseases. - : ELSEVIER SCIENCE INC. - 1550-7289 .- 1878-7533. ; 19:10, s. 1154-1161
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Roux-en-Y gastric bypass (RYGB) among adolescents with obesity results in signif-icant weight loss; however, depot-specific changes have been understudied.Objective: We hypothesized that visceral adipose tissue (VAT) reduction in adolescents undergoing RYGB would be greater than other depots and associated with improvement in cardiometabolic risk factors.Setting: Three specialized treatment centers in Sweden. Methods: Fifty-nine adolescents underwent dual x-ray absorptiometry before surgery and at 1, 2, and 5 years after RYGB. Changes in body composition in multiple depots (total fat, lean body, gynoid fat, android fat, subcutaneous adipose tissue, and VAT) and cardiometabolic risk factors were assessed using multiple linear regression analysis and generalized estimating equations adjusting for age, sex, and baseline risk factor levels. Data are presented as percent change (95% CI) with regression models showing slopes and estimated P values.Results: At 1 year post-RYGB, a significant reduction was observed across all body composition measures (P , .001) with the greatest reduction observed in VAT (-65.1% [-68.7, -61.8]). From year 1 to 5 years post-RYGB, a regain was observed in all depots except lean body mass (1.2% [.3, 2.7], P 5 .105). A sex-specific difference in overall trajectories was only observed in lean body mass with males consistently having higher mean levels. Change in VAT at 1 year correlated with change in triglycerides (slope: .21 mg/dL/kg, P = .034) and fasting plasma insulin (slope: 44 pmol/L/kg, P = .027). Conclusions: Adiposity measures all decreased after RYGB but poorly predicted change in cardio-metabolic risk. Despite significant reductions at 1 year, a steady regain was observed out to 5 years, with values still well below baseline. Further research should consider control group comparison and extended follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Adiposity
- Adolescent
- Body composition
- Metabolic and bariatric
- surgery
- Gastric bypass
- Adiposity; Adolescent; Body composition; Metabolic and bariatric surgery; Gastric bypass
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Beamish, A. J.
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Dengel, O. H.
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Palzer, E. F.
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Gronowitz, Eva, ...
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Kelly, A. S.
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Dengel, D. R.
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visa fler...
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Rudser, K. D.
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Brissman, M.
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Olbers, Torsten
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Dahlgren, Jovann ...
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Flodmark, C. E.
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Marcus, C.
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Ryder, J. R.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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Surgery for Obes ...
- Av lärosätet
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Göteborgs universitet
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Linköpings universitet
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Karolinska Institutet