Sökning: WFRF:(Osmancevic Amra 1968) >
Effects of brodalum...
Effects of brodalumab on psoriasis and depressive symptoms in patients with insufficient response to TNF-α inhibitors
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- Andersch-Björkman, Ylva (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden; Sahlgrens Univ Hosp, Sweden
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- Micu, Emanuela (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland
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- Seifert, Oliver (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Lonne-Rahm, S. B. (författare)
- Malarsjukhuset, Sweden
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- Gillstedt, Martin, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Osmancevic, Amra, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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(creator_code:org_t)
- WILEY, 2023
- 2023
- Engelska.
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Ingår i: Journal of Dermatology. - : WILEY. - 0385-2407 .- 1346-8138. ; 50:11, s. 1401-1414
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The objective of this study was to evaluate emotions of depression and anxiety in psoriatic patients that due to insufficient response to tumor necrosis factor-alpha inhibition (TNF-alpha), underwent a treatment switch from TNF-alpha to interleukin 17 inhibition using brodalumab. The Self-rated Montgomery-Asberg Depression Rating Scale and the Hospital Anxiety and Depression Scale were used to assess depression and anxiety. A total of 20 patients with psoriasis were enrolled in the study. They were monitored for a period of 3 months following the transition to brodalumab treatment. The results showed a significant improvement in both the Psoriasis Area and Severity Index as well as symptoms of depression; anxiety symptoms showed a reduction, though not statistically significant. Perhaps of more interest, the positive effects on depression and anxiety seem to be independent of the reduction in skin related psoriatic lesions. These findings highlight the importance of addressing depressive and anxiety symptoms, together with psoriasis severity and quality of life, when managing patients with psoriasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- anxiety
- brodalumab
- depression
- IL-17 inhibitor
- psoriasis
- anxiety; brodalumab; depression; IL-17 inhibitor; psoriasis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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