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- van Dissel, A. C. (author)
End-stage heart failure in congenitally corrected transposition of the great arteries: a multicentre study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2023
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/331350
- https://gup.ub.gu.se/publication/331350URI
- https://doi.org/10.1093/eurheartj/ehad511DOI
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- Language:English
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- SwePubSwePub
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- Background and Aims For patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear. Methods This multicentre, retrospective cohort study included adults with ccTGA seen at a congenital heart disease centre. Clinical data from initial and most recent visits were obtained. The composite primary outcome was mechanical circulatory support, heart transplantation, or death. Results From 558 patients (48% female, age at first visit 36 & PLUSMN; 14.2 years, median follow-up 8.7 years), the event rate of the primary outcome was 15.4 per 1000 person-years (11 mechanical circulatory support implantations, 12 transplantations, and 52 deaths). Patients experiencing the primary outcome were older and more likely to have a history of atrial arrhythmia. The primary outcome was highest in those with both moderate/severe right ventricular (RV) dysfunction and tricuspid regurgitation (n = 110, 31 events) and uncommon in those with mild/less RV dysfunction and tricuspid regurgitation (n = 181, 13 events, P < .001). Outcomes were not different based on anatomic complexity and history of tricuspid valve surgery or of subpulmonic obstruction. New CHF admission or ventricular arrhythmia was associated with the primary outcome. Individuals who underwent childhood surgery had more adverse outcomes than age- and sex-matched controls. Multivariable Cox regression analysis identified older age, prior CHF admission, and severe RV dysfunction as independent predictors for the primary outcome. Conclusions Patients with ccTGA have variable deterioration to end-stage heart failure or death over time, commonly between their fifth and sixth decades. Predictors include arrhythmic and CHF events and severe RV dysfunction but not anatomy or need for tricuspid valve surgery.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Adult congenital heart disease
- Transposition of the great arteries
- Systemic right ventricle
- Congestive heart failure
- Mechanical
- circulatory support
- Heart transplantation
- atrioventricular valve-replacement
- ventricular dysfunction
- disease
- adults
- outcomes
- impact
- Cardiovascular System & Cardiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Opotowsky, A. R. (author)
- Burchill, L. J. (author)
- Aboulhosn, J. (author)
- Grewal, J. (author)
- Lubert, A. M. (author)
- Antonova, P. (author)
- Shah, S. (author)
- Cotts, T. (author)
- John, A. S. (author)
- Kay, W. A. (author)
- DeZorzi, C. (author)
- Magalski, A. (author)
- Han, F. (author)
- Baker, D. (author)
- Kay, J. (author)
- Yeung, Elzb (author)
- Vonder Muhll, I. (author)
- Pylypchuk, S. (author)
- Kuo, M. C. (author)
- Nicolarsen, J. (author)
- Sarubbi, B. (author)
- Fusco, F. (author)
- Jameson, S. M. (author)
- Cramer, J. (author)
- Gupta, T. (author)
- Gallego, P. (author)
- O'Donnell, C. (author)
- Hannah, J. (author)
- Dellborg, Mikael,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xdelmi (author)
- Kauling, R. M. (author)
- Ginde, S. (author)
- Krieger, E. V. (author)
- Rodriguez, F. (author)
- Dehghani, P. (author)
- Kutty, S. (author)
- Wong, J. S. (author)
- Wilson, W. M. (author)
- Rodriguez-Monserrate, C. P. (author)
- Roos-Hesselink, J. (author)
- Celermajer, D. S. (author)
- Khairy, P. (author)
- Broberg, C. S. (author)
- Göteborgs universitetInstitutionen för medicin (creator_code:org_t)
Related titles
- In:European Heart Journal44:34, s. 3278-32910195-668X
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- Antonova, P.
- Shah, S.
- Cotts, T.
- John, A. S.
- Kay, W. A.
- DeZorzi, C.
- Magalski, A.
- Han, F.
- Baker, D.
- Kay, J.
- Yeung, Elzb
- Vonder Muhll, I.
- Pylypchuk, S.
- Kuo, M. C.
- Nicolarsen, J.
- Sarubbi, B.
- Fusco, F.
- Jameson, S. M.
- Cramer, J.
- Gupta, T.
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- O'Donnell, C.
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- Kauling, R. M.
- Ginde, S.
- Krieger, E. V.
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- Wong, J. S.
- Wilson, W. M.
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