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> Olsson Daniel S 1983
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Long-term Follow-up...
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Himonakos, ChristosKarolinska Institute,Karlstad Hospital
(författare)
Long-term Follow-up of 84 Patients With Giant Prolactinomas-A Swedish Nationwide Study.
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Oxford University Press,2023
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/331439
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https://gup.ub.gu.se/publication/331439URI
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https://doi.org/10.1210/clinem/dgad393DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107309URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217966URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196709URI
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https://lup.lub.lu.se/record/1f30c0a0-692c-40b7-890c-f7001be1a45bURI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153115982URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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To describe the clinical presentation and treatment outcomes in a nationwide cohort of patients with giant prolactinomas.Register-based study of patients with giant prolactinomas [serum prolactin (PRL) > 1000 µg/L, tumor diameter ≥40 mm] identified in the Swedish Pituitary Register 1991-2018.Eighty-four patients [mean age 47 (SD ±16) years, 89% men] were included in the study. At diagnosis, the median PRL was 6305 µg/L (range 1450-253 000), the median tumor diameter was 47 mm (range 40-85), 84% of the patients had hypogonadotropic hypogonadism, and 71% visual field defects. All patients were treated with a dopamine agonist (DA) at some point. Twenty-three (27%) received 1 or more additional therapies, including surgery (n = 19), radiotherapy (n = 6), other medical treatments (n = 4), and chemotherapy (n = 2). Ki-67 was ≥10% in 4/14 tumors. At the last follow-up [median 9 years (interquartile range (IQR) 4-15)], the median PRL was 12 µg/L (IQR 4-126), and the median tumor diameter was 22 mm (IQR 3-40). Normalized PRL was achieved in 55%, significant tumor reduction in 69%, and combined response (normalized PRL and significant tumor reduction) in 43%. In the primary DA-treated patients (n = 79), the reduction in PRL or tumor size after the first year predicted the combined response at the last follow-up (P < .001 and P = .012, respectively).DAs effectively reduced PRL and tumor size, but approximately 1 patient out of 4 needed multimodal treatment. Our results suggest that the response to DA after 1 year is useful for identifying patients who need more careful monitoring and, in some cases, additional treatment.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Burman, PiaLund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-bap
(författare)
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Borg, HenrikLund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)he1116bo
(författare)
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Dahlqvist, PerUmeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden(Swepub:umu)perdat96
(författare)
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Engström, Britt EdénDepartment of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University and Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
(författare)
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Ekman, BertilLinköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)berek83
(författare)
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Emilsson, LouiseKarolinska Institutet,Karolinska Institute,University of Oslo
(författare)
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Olsson, Daniel S,1983Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology at Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden(Swepub:gu)xolssd
(författare)
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Ragnarsson, Oskar,1971Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology at Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xragos
(författare)
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Wahlberg, Jeanette,1969-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Örebro University Hospital, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Sweden,Orebro Univ Hosp, Sweden; Orebro Univ, Sweden(Swepub:oru)jewg
(författare)
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Åkerman, Anna-KarinKarolinska Institute,Örebro University Hospital
(författare)
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Höybye, CharlotteKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Berinder, KatarinaKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Karolinska InstituteKarlstad Hospital
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Journal of clinical endocrinology and metabolism: Oxford University Press108:121945-71970021-972X
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Till lärosätets databas
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Himonakos, Chris ...
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Burman, Pia
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Borg, Henrik
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Dahlqvist, Per
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Engström, Britt ...
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Ekman, Bertil
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Emilsson, Louise
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Olsson, Daniel S ...
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Ragnarsson, Oska ...
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Wahlberg, Jeanet ...
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Åkerman, Anna-Ka ...
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Höybye, Charlott ...
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Berinder, Katari ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- Av lärosätet
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Göteborgs universitet
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Örebro universitet
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Umeå universitet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet