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  • Linde, L.Copenhagen University Hospital,University of Copenhagen (author)

Predictors of DAPSA28 remission in patients with psoriatic arthritis initiating a first TNF inhibitor: results from 13 European registries

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024

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  • LIBRIS-ID:oai:gup.ub.gu.se/331555
  • https://gup.ub.gu.se/publication/331555URI
  • https://doi.org/10.1093/rheumatology/kead284DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153447658URI
  • https://lup.lub.lu.se/record/fbf3b100-aed3-4594-9218-1d6a0fcff35eURI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objectives In bio-naive patients with PsA initiating a TNF inhibitor (TNFi), we aimed to identify baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission (primary objective) and DAPSA28 moderate response at 6 months, as well as drug retention at 12 months across 13 European registries. Methods Baseline demographic and clinical characteristics were retrieved and the three outcomes investigated per registry and in pooled data, using logistic regression analyses on multiply imputed data. In the pooled cohort, selected predictors that were either consistently positive or negative across all three outcomes were defined as common predictors. Results In the pooled cohort (n = 13 369), 6-month proportions of remission, moderate response and 12-month drug retention were 25%, 34% and 63% in patients with available data (n = 6954, n = 5275 and n = 13 369, respectively). Five common baseline predictors of remission, moderate response and 12-month drug retention were identified across all three outcomes. The odds ratios (95% CIs) for DAPSA28 remission were: age, per year: 0.97 (0.96-0.98); disease duration, years (<2 years as reference): 2-3 years: 1.20 (0.89-1.60), 4-9 years: 1.42 (1.09-1.84), & GE;10 years: 1.66 (1.26-2.20); men vs women: 1.85 (1.54-2.23); CRP of >10 vs & LE;10 mg/l: 1.52 (1.22-1.89) and 1 mm increase in patient fatigue score: 0.99 (0.98-0.99). Conclusion Baseline predictors of remission, response and adherence to TNFi therapy were identified, of which five were common for all three outcomes, indicating that the predictors emerging from our pooled cohort may be considered generalizable from country level to disease level.

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  • Ornbjerg, L. M.Copenhagen University Hospital (author)
  • Georgiadis, S.Copenhagen University Hospital (author)
  • Rasmussen, S. H. (author)
  • Lindström, UlfUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy(Swepub:gu)xlulfn (author)
  • Askling, J.Karolinska Institute,Karolinska Institutet (author)
  • Michelsen, B.Diakonhjemmet Hospital,Sørlandet Hospital (author)
  • Di Giuseppe, D.Karolinska Institute,Karolinska Institutet (author)
  • Wallman, Johan K.Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jnk (author)
  • Gudbjornsson, B.National University Hospital of Iceland (author)
  • Love, T. J.National University Hospital of Iceland (author)
  • Nordstrom, D. C.Helsinki University Central Hospital,Carol Davila University of Medicine and Pharmacy (author)
  • Yli-Kerttula, T.Satakunta Central Hospital (author)
  • Nekvindova, L.Charles University in Prague,Institute of Rheumatology, Prague (author)
  • Vencovsky, J.Charles University in Prague,Institute of Rheumatology, Prague (author)
  • Iannone, F.University of Bari Aldo Moro (author)
  • Cauli, A.University of Cagliari (author)
  • Loft, A. G.Aarhus University Hospital,Aarhus University (author)
  • Glintborg, B.University of Copenhagen,Copenhagen University Hospital (author)
  • Laas, K. (author)
  • Rotar, Z.University of Ljubljana,University Medical Centre Ljubljana (author)
  • Tomsic, M.University Medical Centre Ljubljana,University of Ljubljana (author)
  • Macfarlane, G. J. (author)
  • Moller, B.Bern University Hospital (author)
  • van de Sande, M.University of Amsterdam (author)
  • Codreanu, C. (author)
  • Nissen, M. J.Geneva University Hospital (author)
  • Birlik, M.Dokuz Eylül University (author)
  • Erten, S. (author)
  • Santos, M. J.Hospital Garcia de Orta (author)
  • Vieira-Sousa, E.University of Lisbon (author)
  • Hetland, M. L. (author)
  • Ostergaard, M.University of Copenhagen (author)
  • Copenhagen University HospitalUniversity of Copenhagen (creator_code:org_t)

Related titles

  • In:Rheumatology63:3, s. 751-7641462-0324
  • In:Rheumatology (Oxford, England)63:3, s. 751-7641462-0332

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