Search: WFRF:(Kihlberg J.) >
Antigen-presenting ...
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice
-
- Aoun, M. (author)
- Karolinska Institutet
-
- Coelho, A. (author)
- Karolinska Institutet
-
- Krämer, A. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.
-
show more...
-
- Saxena, A. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.
-
- Sabatier, P. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Solna, Sweden.
-
- Beusch, C. M. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Solna, Sweden.
-
- Lönnblom, E. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.
-
- Geng, M. M. (author)
- Xian JiaotongUniv, Precis Med Inst, Affiliated Hosp 2, Xian, Peoples R China.
-
- Do, N. N. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.;Fraunhofer Inst Translat Med & Pharmacol, Frankfurt, Germany.;Fraunhofer Cluster Excellence Immune Mediated Dis, Frankfurt, Germany.
-
- Xu, Z. W. (author)
- Karolinska Institutet
-
- Zhang, J. D. (author)
- Karolinska Inst, Max Planck Inst Biol Ageing, Karolinska Inst Lab, Solna, Sweden.;Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Metab, Solna, Sweden.
-
- He, Y. B. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.
-
- Castillo, L. R. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.
-
- Abolhassani, H. (author)
- Karolinska Institutet
-
- Xu, B. Z. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.
-
- Viljanen, Johan V. (author)
- Uppsala universitet,Organisk kemi,Uppsala Univ, Sweden
-
- Rorbach, J. (author)
- Karolinska Institutet
-
- Lahore, G. F. (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden.
-
- Gjertsson, Inger, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
-
- Kastbom, Alf (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
-
- Sjöwall, Christopher (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
-
- Kihlberg, Jan (author)
- Uppsala universitet,Organisk kemi,Uppsala Univ, Sweden
-
- Zubarev, R. A. (author)
- Karolinska Institutet
-
- Burkhardt, H. (author)
- Fraunhofer Inst Translat Med & Pharmacol, Frankfurt, Germany.;Fraunhofer Cluster Excellence Immune Mediated Dis, Frankfurt, Germany.;Goethe Univ, Univ Hosp Frankfurt, Div Rheumatol, Frankfurt am Main, Germany.
-
- Holmdahl, R. (author)
- Karolinska Institutet
-
show less...
-
Karolinska Institutet Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, Solna, Sweden (creator_code:org_t)
-
-
show more...
-
-
show less...
- ISSN 0022-1007
- Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics, 2023
- 2023
- English.
-
In: Journal of Experimental Medicine. - Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics. - 0022-1007 .- 1540-9538. ; 220:11
- Related links:
-
http://hdl.handle.ne... (primary) (Object in context) (free)
-
show more...
-
https://liu.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
http://hdl.handle.ne...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, we traced natural autoreactive B cells (C1-B) specific for a defined triple-helical epitope on collagen type-II (COL2), constituting a sizeable fraction of the physiological B cell repertoire in mice, rats, and humans. Adoptive transfer of C1-B suppressed arthritis independently of IL10, separating them from IL10-secreting regulatory B cells. Single-cell sequencing revealed an antigen processing and presentation signature, including induced expression of CD72 and CCR7 as surface markers. C1-B presented COL2 to T cells and induced the expansion of regulatory T cells in a contact-dependent manner. CD72 blockade impeded this effect suggesting a new downstream suppressor mechanism that regulates antigen-specific T cell tolerization. Thus, our results indicate that autoreactive antigen-specific naive B cells tolerize infiltrating T cells against self-antigens to impede the development of tissue-specific autoimmune inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- collagen-induced arthritis
- reduced oxidative burst
- ii collagen
- rheumatoid-arthritis
- somatic hypermutation
- self-antigens
- b10 cells
- antibodies
- mouse
- expression
- Immunology
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Aoun, M.
-
Coelho, A.
-
Krämer, A.
-
Saxena, A.
-
Sabatier, P.
-
Beusch, C. M.
-
show more...
-
Lönnblom, E.
-
Geng, M. M.
-
Do, N. N.
-
Xu, Z. W.
-
Zhang, J. D.
-
He, Y. B.
-
Castillo, L. R.
-
Abolhassani, H.
-
Xu, B. Z.
-
Viljanen, Johan ...
-
Rorbach, J.
-
Lahore, G. F.
-
Gjertsson, Inger ...
-
Kastbom, Alf
-
Sjöwall, Christo ...
-
Kihlberg, Jan
-
Zubarev, R. A.
-
Burkhardt, H.
-
Holmdahl, R.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Journal of Exper ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet
-
Uppsala University
-
Linköping University