Search: id:"swepub:oai:gup.ub.gu.se/331813" >
Predictors for Prol...
Predictors for Prolonged Hospital Stay Solely to Complete Intravenous Antifungal Treatment in Patients with Candidemia: Results from the ECMM Candida III Multinational European Observational Cohort Study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/331813
-
https://gup.ub.gu.se/publication/331813URI
-
https://doi.org/10.1007/s11046-023-00776-4DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates of azole resistance among non-albicans Candida spp. continue to increase. The objective of this sub-analysis of the European multicenter observational cohort study Candida III was to describe demographical and clinical characteristics of the cohort requiring prolonged hospitalization solely to complete intravenous (iv) antifungal treatment (AF Tx). Methods Each participating hospital (number of eligible hospitals per country determined by population size) included the first * 10 blood culture proven adult candidemia cases occurring consecutively after July 1st, 2018, and treating physicians answered the question on whether hospital stay was prolonged only for completion of intravenous antifungal therapy. Descriptive analyses as well as binary logistic regression was used to assess for predictors of prolonged hospitalization solely to complete iv AF Tx. Findings Hospital stay was prolonged solely for the completion of iv AF Tx in 16% (100/621) of candidemia cases by a median of 16 days (IQR 8 - 28). In the multivariable model, initial echinocandin treatment was a positive predictor for prolonged hospitalization to complete iv AF Tx (aOR 2.87, 95% CI 1.55 - 5.32, p < 0.001), while (i) neutropenia, (ii) intensive care unit admission, (iii) catheter related candidemia, (iv) total parenteral nutrition, and (v) C. parapsilosis as causative pathogen were found to be negative predictors (aOR 0.22 - 0.45; p < 0.03). Interpretation Hospital stays were prolonged due to need of iv AF Tx in 16% of patients with candidemia. Those patients were more likely to receive echinocandins as initial treatment and were less severely ill and less likely infected with C. parapsilosis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Salmanton-García, J.
(author)
-
Barac, A.
(author)
-
Gangneux, J. P.
(author)
-
Guegan, H.
(author)
-
Arsic-Arsenijevic, V.
(author)
-
Matos, T.
(author)
-
Tomazin, R.
(author)
-
Klimko, N.
(author)
-
Bassetti, M.
(author)
-
Hammarström, HelenaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xhahel
(author)
-
Meijer, E. F. J.
(author)
-
Meis, J. F.
(author)
-
Prattes, J.
(author)
-
Krause, R.
(author)
-
Sipahi, O. R.
(author)
-
Scharmann, U.
(author)
-
White, P. L.
(author)
-
Desoubeaux, G.
(author)
-
García-Rodríguez, J.
(author)
-
Garcia-Vidal, C.
(author)
-
Martín-Pérez, S.
(author)
-
Ruiz, M.
(author)
-
Tumbarello, M.
(author)
-
Talento, A. F.
(author)
-
Rogers, B.
(author)
-
Lagrou, K.
(author)
-
van Praet, J.
(author)
-
Arikan-Akdagli, S.
(author)
-
Arendrup, M. C.
(author)
-
Koehler, P.
(author)
-
Cornely, O. A.
(author)
-
Hoenigl, M.
(author)
-
Ecmm Candida III Study Grp, Ecmm Candida III Study Grp
(author)
-
Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
Related titles
-
In:Mycopathologia188:6, s. 983-9940301-486X
Internet link
Find in a library
To the university's database
- By the author/editor
-
Egger, M.
-
Salmanton-García ...
-
Barac, A.
-
Gangneux, J. P.
-
Guegan, H.
-
Arsic-Arsenijevi ...
-
show more...
-
Matos, T.
-
Tomazin, R.
-
Klimko, N.
-
Bassetti, M.
-
Hammarström, Hel ...
-
Meijer, E. F. J.
-
Meis, J. F.
-
Prattes, J.
-
Krause, R.
-
Sipahi, O. R.
-
Scharmann, U.
-
White, P. L.
-
Desoubeaux, G.
-
García-Rodríguez ...
-
Garcia-Vidal, C.
-
Martín-Pérez, S.
-
Ruiz, M.
-
Tumbarello, M.
-
Talento, A. F.
-
Rogers, B.
-
Lagrou, K.
-
van Praet, J.
-
Arikan-Akdagli, ...
-
Arendrup, M. C.
-
Koehler, P.
-
Cornely, O. A.
-
Hoenigl, M.
-
Ecmm Candida III ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
- Articles in the publication
-
Mycopathologia
- By the university
-
University of Gothenburg