Search: WFRF:(Pascoal A)
> (2020-2024) >
14-3-3 ζ/δ-reported...
14-3-3 ζ/δ-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2
-
Woo, M. S. (author)
-
Nilsson, J. (author)
-
Therriault, J. (author)
-
show more...
-
Rahmouni, N. (author)
-
Brinkmalm, A. (author)
-
- Lessa Benedet, Andréa (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Macedo, A. C. (author)
-
Servaes, S. (author)
-
Wang, Y. T. (author)
-
Tissot, C. (author)
-
Arias, J. F. (author)
-
Hosseini, S. A. (author)
-
Chamoun, M. (author)
-
Lussier, F. Z. (author)
-
- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Stevenson, J. (author)
-
Mayer, C. (author)
-
Ferrari-Souza, J. P. (author)
-
Kobayashi, E. (author)
-
Massarweh, G. (author)
-
Friese, M. A. (author)
-
Pascoal, T. A. (author)
-
Gauthier, S. (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Rosa-Neto, P. (author)
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Journal of Neuroinflammation. - 1742-2094. ; 20:1
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Introduction Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer's disease (AD). However, synaptic damage happens early in AD at the very early stages of tau accumulation. It remains unclear whether microglia activation independently causes synaptic cleavage before tau aggregation appears.Methods We investigated 104 participants across the AD continuum by measuring 14-3-3 zeta/delta (zeta/delta) as a cerebrospinal fluid biomarker for synaptic degradation, and fluid and imaging biomarkers of tau, amyloidosis, astrogliosis, neurodegeneration, and inflammation. We performed correlation analyses in cognitively unimpaired and impaired participants and used structural equation models to estimate the impact of microglia activation on synaptic injury in different disease stages.Results14-3-3 zeta/delta was increased in participants with amyloid pathology at the early stages of tau aggregation before hippocampal volume loss was detectable. 14-3-3 zeta/delta correlated with amyloidosis and tau load in all participants but only with biomarkers of neurodegeneration and memory deficits in cognitively unimpaired participants. This early synaptic damage was independently mediated by sTREM2. At later disease stages, tau and astrogliosis additionally mediated synaptic loss.ConclusionsOur results advertise that sTREM2 is mediating synaptic injury at the early stages of tau accumulation, underlining the importance of microglia activation for AD disease propagation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- sTREM2
- Microglia
- Neuroinflammation
- Synaptic loss
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Woo, M. S.
-
Nilsson, J.
-
Therriault, J.
-
Rahmouni, N.
-
Brinkmalm, A.
-
Lessa Benedet, A ...
-
show more...
-
Ashton, Nicholas ...
-
Macedo, A. C.
-
Servaes, S.
-
Wang, Y. T.
-
Tissot, C.
-
Arias, J. F.
-
Hosseini, S. A.
-
Chamoun, M.
-
Lussier, F. Z.
-
Karikari, Thomas
-
Stevenson, J.
-
Mayer, C.
-
Ferrari-Souza, J ...
-
Kobayashi, E.
-
Massarweh, G.
-
Friese, M. A.
-
Pascoal, T. A.
-
Gauthier, S.
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Rosa-Neto, P.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Journal of Neuro ...
- By the university
-
University of Gothenburg