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Opportunistic prost...
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Albertsen, P. C.
(författare)
Opportunistic prostate-specific antigen testing in Norwegian men: a public health challenge
- Artikel/kapitelEngelska2024
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LIBRIS-ID:oai:gup.ub.gu.se/331991
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https://gup.ub.gu.se/publication/331991URI
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https://doi.org/10.1111/bju.16211DOI
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Ämneskategori:art swepub-publicationtype
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Objective To describe age-specific prostate-specific antigen (PSA) distributions and resulting prostate cancer diagnoses that arise from population-wide opportunistic PSA testing.Patients and Methods Over 8 million PSA tests were performed on >1.4 million Norwegian men from 2000 to 2020. During this period 43 486 men were diagnosed with localised prostate cancer. Most of the PSA testing reflected opportunistic testing. Age-specific PSA value distributions were constructed for men aged 45-75 years with and without prostate cancer.Results The distributions of PSA values in men with and without prostate cancer widened with age and overlapped extensively from 3 to 7 ng/mL. Localised prostate cancer diagnoses increased 10-fold from the age of 45 to 75 years. PSA testing identified intermediate- or high-grade cancers in 21% (95% confidence interval [CI] 19-23%) of men aged 50-54 years and 42% (95% CI 41-43%) of men aged 70-74 years. Grade group (GG)1, GG2, GG3 and >= GG4 constituted 49%, 31%, 10% and 10% of cancers identified at age 50-54 years and 26%, 26%, 18%, and 30% of cancers identified at age 70-74 years.Conclusion Opportunistic PSA testing increases with ageing and often generates values that cannot discriminate benign prostate enlargement from prostate cancer. A clinical cascade using additional imaging or serum tests is necessary to avoid negative biopsies and the overdiagnosis of indolent disease. The declining specificity of PSA testing with ageing poses a significant public health challenge especially among older men aged >= 70 years.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bjerner, L. J.
(författare)
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Pasovic, L.
(författare)
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Müller, S.
(författare)
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Fosså, S.
(författare)
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Carlsson, Sigrid VGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
(författare)
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Oldenburg, J.
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för urologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Bju International133:1, s. 104-1111464-4096
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