Search: WFRF:(Kohler Verena 1992 ) >
Early fate decision...
Early fate decision for mitochondrially encoded proteins by a molecular triage
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- Kohler, Andreas, Dr. rer. nat. 1988- (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria
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- Carlström, Andreas (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Nolte, H. (author)
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- Kohler, Verena, 1992- (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria
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- Jung, Sung-Jun, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Sridhara, Sagar, 1989 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Tatsuta, T. (author)
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- Berndtsson, Jens, 1989- (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Langer, T. (author)
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- Ott, Martin, 1974 (author)
- Stockholms universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Institutionen för biokemi och biofysik,University of Gothenburg, Sweden
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(creator_code:org_t)
- Cell Press, 2023
- 2023
- English.
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In: Molecular Cell. - : Cell Press. - 1097-2765 .- 1097-4164. ; 83:19
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Abstract
Subject headings
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- Folding of newly synthesized proteins poses challenges for a functional proteome. Dedicated protein quality control (PQC) systems either promote the folding of nascent polypeptides at ribosomes or, if this fails, ensure their degradation. Although well studied for cytosolic protein biogenesis, it is not understood how these processes work for mitochondrially encoded proteins, key subunits of the oxidative phosphorylation (OXPHOS) system. Here, we identify dedicated hubs in proximity to mitoribosomal tunnel exits coordinating mitochondrial protein biogenesis and quality control. Conserved prohibitin (PHB)/m-AAA protease supercomplexes and the availability of assembly chaperones determine the fate of newly synthesized proteins by molecular triaging. The localization of these competing activities in the vicinity of the mitoribosomal tunnel exit allows for a prompt decision on whether newly synthesized proteins are fed into OXPHOS assembly or are degraded.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kohler, Andreas, ...
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Carlström, Andre ...
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Nolte, H.
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Kohler, Verena, ...
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Jung, Sung-Jun, ...
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Sridhara, Sagar, ...
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show more...
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Tatsuta, T.
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Berndtsson, Jens ...
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Langer, T.
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Ott, Martin, 197 ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Molecular Cell
- By the university
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University of Gothenburg
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Stockholm University
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Umeå University