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  • Sanchez Klose, Felix,1989Chalmers tekniska högskola,Chalmers University of Technology (author)

The Pseudomonas aeruginosa lectin LecB modulates intracellular reactive oxygen species production in human neutrophils

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/332028
  • https://gup.ub.gu.se/publication/332028URI
  • https://doi.org/10.1002/eji.202350623DOI
  • https://research.chalmers.se/publication/538630URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Pseudomonas aeruginosa is a Gram-negative bacterium and an opportunistic pathogen ubiquitously present throughout nature. LecB, a fucose-, and mannose-binding lectin, is a prominent virulence factor of P. aeruginosa, which can be expressed on the bacterial surface but also be secreted. However, the LecB interaction with human immune cells remains to be characterized. Neutrophils comprise the first line of defense against infections and their production of reactive oxygen species (ROS) and release of extracellular traps (NETs) are critical antimicrobial mechanisms. When profiling the neutrophil glycome we found several glycoconjugates on granule and plasma membranes that could potentially act as LecB receptors. In line with this, we here show that soluble LecB can activate primed neutrophils to produce high levels of intracellular ROS (icROS), an effect that was inhibited by methyl fucoside. On the other hand, soluble LecB inhibits P. aeruginosa-induced icROS production. In support of that, during phagocytosis of wild-type and LecB-deficient P. aeruginosa, bacteria with LecB induced less icROS production as compared with bacteria lacking the lectin. Hence, LecB can either induce or inhibit icROS production in neutrophils depending on the circumstances, demonstrating a novel and potential role for LecB as an immunomodulator of neutrophil functional responses.

Subject headings and genre

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  • Dahlstrand Rudin, AgnesGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,University of Gothenburg(Swepub:gu)xdahis (author)
  • Bergqvist, LindaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg (author)
  • Scheffler, Julia,1982Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg(Swepub:gu)xscjul (author)
  • Jönsson, Katarina,1991Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,University of Gothenburg(Swepub:gu)xjkata (author)
  • Islander, Ulrika,1975Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg(Swepub:gu)xislul (author)
  • Karlsson-Bengtsson, AnnaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)ankarls (author)
  • Bylund, Johan,1975Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,University of Gothenburg(Swepub:gu)xbyljo (author)
  • Venkatakrishnan, Vignesh,1987Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)vigven (author)
  • Chalmers tekniska högskolaInstitutionen för odontologi (creator_code:org_t)

Related titles

  • In:European Journal of Immunology54:20014-29801521-4141

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