Search: WFRF:(Hoeft A)
> (2020-2023) >
Gut inflammation as...
Gut inflammation associated with age and Alzheimer's disease pathology: a human cohort study
-
Heston, M. B. (author)
-
Hanslik, K. L. (author)
-
Zarbock, K. R. (author)
-
show more...
-
Harding, S. J. (author)
-
Davenport-Sis, N. J. (author)
-
Kerby, R. L. (author)
-
Chin, N. (author)
-
Sun, Y. (author)
-
Hoeft, A. (author)
-
Deming, Y. (author)
-
Vogt, N. M. (author)
-
Betthauser, T. J. (author)
-
Johnson, S. C. (author)
-
Asthana, S. (author)
-
Kollmorgen, G. (author)
-
Suridjan, I. (author)
-
Wild, N. (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Rey, F. E. (author)
-
Bendlin, B. B. (author)
-
Ulland, T. K. (author)
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Scientific Reports. - 2045-2322. ; 13:1
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Age-related disease may be mediated by low levels of chronic inflammation ("inflammaging"). Recent work suggests that gut microbes can contribute to inflammation via degradation of the intestinal barrier. While aging and age-related diseases including Alzheimer's disease (AD) are linked to altered microbiome composition and higher levels of gut microbial components in systemic circulation, the role of intestinal inflammation remains unclear. To investigate whether greater gut inflammation is associated with advanced age and AD pathology, we assessed fecal samples from older adults to measure calprotectin, an established marker of intestinal inflammation which is elevated in diseases of gut barrier integrity. Multiple regression with maximum likelihood estimation and Satorra-Bentler corrections were used to test relationships between fecal calprotectin and clinical diagnosis, participant age, cerebrospinal fluid biomarkers of AD pathology, amyloid burden measured using 11C-Pittsburgh compound B positron emission tomography (PiB PET) imaging, and performance on cognitive tests measuring executive function and verbal learning and recall. Calprotectin levels were elevated in advanced age and were higher in participants diagnosed with amyloid-confirmed AD dementia. Additionally, among individuals with AD dementia, higher calprotectin was associated with greater amyloid burden as measured with PiB PET. Exploratory analyses indicated that calprotectin levels were also associated with cerebrospinal fluid markers of AD, and with lower verbal memory function even among cognitively unimpaired participants. Taken together, these findings suggest that intestinal inflammation is linked with brain pathology even in the earliest disease stages. Moreover, intestinal inflammation may exacerbate the progression toward AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Heston, M. B.
-
Hanslik, K. L.
-
Zarbock, K. R.
-
Harding, S. J.
-
Davenport-Sis, N ...
-
Kerby, R. L.
-
show more...
-
Chin, N.
-
Sun, Y.
-
Hoeft, A.
-
Deming, Y.
-
Vogt, N. M.
-
Betthauser, T. J ...
-
Johnson, S. C.
-
Asthana, S.
-
Kollmorgen, G.
-
Suridjan, I.
-
Wild, N.
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Rey, F. E.
-
Bendlin, B. B.
-
Ulland, T. K.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Scientific Repor ...
- By the university
-
University of Gothenburg