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Flexible and Biocom...
Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions
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- Berglin, Mattias, 1970 (author)
- RISE,Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Metodik för produktframtagning,University of Gothenburg, Sweden
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- Cavanagh, Jorunn Pauline (author)
- Amicoat A/S, Norway; UiT The Arctic University of Norway, Norway
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- Caous, Josefin Seth (author)
- RISE,Metodik för produktframtagning
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- Thakkar, Balmukund Sureshkumar (author)
- Amicoat A/S, Norway
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- Vasquez, Jeddah Marie (author)
- RISE,Metodik för produktframtagning
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- Stensen, Wenche (author)
- UiT The Arctic University of Norway, Norway
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- Lyvén, Benny (author)
- RISE,Metodik för produktframtagning
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- Svenson, Johan (author)
- RISE,Material och produktion
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Svenson, Johan (author)
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(creator_code:org_t)
- John Wiley and Sons Inc, 2024
- 2024
- English.
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In: Macromolecular Bioscience. - : John Wiley and Sons Inc. - 1616-5187 .- 1616-5195. ; 24:4
- Related links:
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https://doi.org/10.1...
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https://ri.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing different polyolic polytetrahydrofurans, isocyanates, and chain extenders, a robust and flexible material comparable to commercial thermoplastic polyurethane is prepared. A series of short synthetic antimicrobial peptides are designed, synthesized, and covalently attached in a single coupling step to generate a homogenous coating. The lead material is shown to be biocompatible and does not display any toxicity against either mouse fibroblasts or reconstructed human epidermis according to ISO and OECD guidelines. The repelling performance of the peptide-coated materials is illustrated against colonization and biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis on coated plastic films and finally, on coated commercial central venous catheters employing LIVE/DEAD staining, confocal laser scanning microscopy, and bacterial counts. This study presents the successful development of a versatile and scalable polyurethane with the potential for use in the medical field to reduce the impact of bacterial biofilms.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
Keyword
- antimicrobial peptide
- biocompatible
- click chemistry
- flexible
- polyurethane
- Bacteria; Biocompatibility; Biofilms; Cell culture; Coated materials; Crosslinking; Peptides; Plastic coatings; Reinforced plastics; Anti-foulings; Antibacterial materials; Antimicrobial peptide; Biocompatible; Click chemistry; Click reaction; Flexible; Implant-associated infection; On demands; Simple++; Polyurethanes
Publication and Content Type
- ref (subject category)
- art (subject category)
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