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Anti-Toxin Response...
Anti-Toxin Responses to Natural Enterotoxigenic Escherichia coli (ETEC) Infection in Adults and Children in Bangladesh
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Girardi, P. (author)
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Bhuiyan, T. R. (author)
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- Lundin, Samuel B, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Harutyunyan, S. (author)
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Neuhauser, I. (author)
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Khanam, F. (author)
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Nagy, G. (author)
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Szijártó, V. (author)
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Henics, T. (author)
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Nagy, E. (author)
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- Harandi, Ali M, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Qadri, F. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Microorganisms. - 2076-2607. ; 11:10
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Subject headings
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- A sero-epidemiology study was conducted in Dhaka, Bangladesh between January 2020 and February 2021 to assess the immune responses to ETEC infection in adults and children. (1) Background: Enterotoxigenic Escherichia coli infection is a main cause of diarrheal disease in endemic countries. The characterization of the immune responses evoked by natural infection can guide vaccine development efforts. (2) Methods: A total of 617 adult and 480 pediatric diarrheal patients were screened, and 43 adults and 46 children (below 5 years of age) with an acute ETEC infection completed the study. The plasma samples were analyzed for antibody responses against the ETEC toxins. (3) Results: Heat-stable toxin (ST)-positive ETEC is the main cause of ETEC infection in adults, unlike in children in an endemic setting. We detected very low levels of anti-ST antibodies, and no ST-neutralizing activity. However, infection with ETEC strains expressing the heat-labile toxin (LT) induced systemic antibody responses in less than 25% of subjects. The antibody levels against LTA and LTB, as well as cholera toxin (CT), correlated well. The anti-LT antibodies were shown to have LT- and CT- neutralizing activity. The antibody reactivity against linear LT epitopes did not correlate with toxin-neutralizing activity. (4) Conclusions: Unlike LT, ST is a poor antigen and even adults have low anti-ST antibody levels that do not allow for the detection of toxin-neutralizing activity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- ETEC
- heat-labile toxin (LT)
- heat-stable toxin (ST)
- natural infection
- endemic population
- children
- research-and-development
- heat-labile
- developing-countries
- toxin-b
- diarrhea
- vaccine
- peptide
- epitope
- disease
- burden
- Microbiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Girardi, P.
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Bhuiyan, T. R.
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Lundin, Samuel B ...
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Harutyunyan, S.
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Neuhauser, I.
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Khanam, F.
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show more...
-
Nagy, G.
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Szijártó, V.
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Henics, T.
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Nagy, E.
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Harandi, Ali M, ...
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Qadri, F.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Microorganisms
- By the university
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University of Gothenburg