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Obstructive sleep a...
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Holtstrand Hjälm, HenrikGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy
(författare)
Obstructive sleep apnea severity and prevalent atrial fibrillation in a sleep clinic cohort with versus without excessive daytime sleepiness
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:gup.ub.gu.se/332263
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https://gup.ub.gu.se/publication/332263URI
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https://doi.org/10.1016/j.sleep.2023.09.012DOI
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https://lup.lub.lu.se/record/a90b04ec-fcfb-4d6e-b27e-9f6ca30f7612URI
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Background: Obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF) in cardiac cohorts. Less is known regarding the magnitude of this association in a sleep clinic cohort with vs. without excessive daytime sleepiness (EDS). Objectives: To explore the association of OSA severity with AF in a sleep clinic cohort stratified by EDS. Patients and methods: All consecutive adults (n = 3814) admitted to the Skaraborg Hospital, Sweden between Jan 2005 and December 2011 were registered in a local database, and the follow-up ended in December 2018. OSA was defined as an apnea-hypopnea index (AHI) >= 5 events/h. Mild OSA was defined as AHI >= 5 & AHI<15 events/ h; moderate OSA as AHI >= 15 & AHI<30 events/h; and severe OSA as AHI >= 30 events/h. EDS was defined as an Epworth Sleepiness Scale score >= 11. We conducted cross-sectional analyzes of the prevalent AF across the OSA severity categories and logistic regression analyzes stratified by EDS.Results: In all, 202 patients (5.3%) had AF at baseline, 1.6% in no-OSA, 3.9% in mild OSA, 5.2% in moderate OSA, and 7.6% in severe OSA, respectively (p < 0.001). The stratified analyzes revealed that patients with severe OSA without EDS had an increased risk for prevalent AF (OR 2.54, 95% CI 1.05-6.16; p = 0.039) independent of the confounding factors. Conclusions: There was an independent dose-response relationship between OSA and prevalent AF among the non-sleepy phenotype in this sleep clinic cohort. Since adherence to OSA treatment is challenging in the absence of EDS, these patients may have increased risk for adverse cardiovascular outcomes.
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Thunström, Erik,1980Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy(Swepub:gu)xthuer
(författare)
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Glantz, H.Skaraborg Hospital
(författare)
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Karlsson, M.Skaraborg Hospital
(författare)
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Celik, Y.Koc University
(författare)
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Peker, Yüksel,1961Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Sahlgrenska Academy,University of Pittsburgh,Brigham and Women's Hospital / Harvard Medical School(Swepub:lu)yu6542pe
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Sleep Medicine112, s. 63-691389-9457
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